Publications by authors named "Silvia Mancinelli"
Article Synopsis
- Interstitial lung diseases (ILDs), especially idiopathic pulmonary fibrosis (IPF), lead to severe lung scarring, increased lung cancer risk, and poor patient outcomes, with a high incidence of mortality.
- A study analyzed a cohort of 73 ILD patients with lung cancer, primarily focusing on 55 with comprehensive data, discovering significant predictors such as age at diagnosis, comorbidities, and gender differences in survival rates.
- Key findings indicate that most tumors were adenocarcinomas, early detection is common, and factors like surgical treatment and autoantibody presence are important for predicting patient survival outcomes in those with IPF-associated lung cancer.
Article Synopsis
- Alpha-1 Antitrypsin Deficiency (AATD) is linked to higher risks of lung and liver diseases, primarily associated with the common PI*ZZ genotype.
- Researchers studied patients with severe AATD from the Italian Registry for AATD, focusing on those with rare genotypes like PI*R.
- Results showed that patients with rare genotypes exhibited similar clinical characteristics and respiratory profiles to those with the PI*ZZ genotype, emphasizing the need for timely diagnosis of PI*R for effective management.
Vaccination coverages need to be constantly maintained and improved with the implementation of vaccination strategies. This paper describes the development of an evidence-based tool to guide their planning and evaluation. A scoping review was performed in MEDLINE and institutional websites to search for similar available tools.
View Article and Find Full Text PDFObjectives: Pneumonia still remains a problem from the clinical and public health viewpoint because of the relevant epidemiological burden. The etiological diagnosis is important in the light of avoiding unnecessary antibiotic treatment and choosing the most appropriate therapeutical approach. This study is aimed at providing evidence on the proportion of microbiological ascertainment in pneumonia-related hospitalizations in one of the most important teaching hospitals in Rome.
View Article and Find Full Text PDFThe World Health Organization (WHO), the United States (US) Centers for Disease Control and Prevention (CDC), the European Center for Disease Control (ECDC), and the immunization guidelines of many countries issue vaccination recommendations for adults and the elderly. However, the uptake of vaccination in these groups is generally low due to several reasons. The present study aimed to identify strategies implemented in Italy in unconventional settings to promote vaccination against influenza, pneumococcal, and herpes zoster virus (HZV) infections among these subjects, i.
View Article and Find Full Text PDFBackground: The assessment of minimal residual disease (MRD) by flow cytometry (FC) has a prognostic impact in acute myeloid leukemia (AML), despite the low sensitivity in predicting relapse. Nonetheless, the role of leukemic-associated immunophenotypes (LAIPs)-related specificity on the sensitivity of MRD has not been clarified yet. In this respect, we accomplished this study.
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