New morpholine-containing pyrimidinones act on α-adrenoceptors.

Drugs that act on α-adrenoceptors may contain morpholine and pyrimidinone heterocycles. The aim of this study was to synthesize a series of pyrimidinones (S6a-e and S8) and characterize their α-adrenoceptor activity. Cytotoxicity assays (MTT and LDH) were performed in A7r5 and HUVECs.

A Concise and Useful Guide to Understand How Alpha Adrenoceptor Antagonists Work.

Adrenoceptors are the receptors for catecholamines, adrenaline, and noradrenaline. They are divided in α (α and α) and β (β, β and β). α-adrenoceptors are subdivided in α, α and α.