Publications by Silvia Luna Lazzara

Publications by authors named "Silvia Luna Lazzara"

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Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect.

Romain Sanson Silvia Luna Lazzara David Cune Caterina Luana Pitasi Coralie Trentesaux

Cell Mol Gastroenterol Hepatol

February 2023

Background & Aims: Axin1 is a negative regulator of wingless-type MMTV integration site family, member 1 (Wnt)/β-catenin signaling with tumor-suppressor function. The Wnt pathway has a critical role in the intestine, both during homeostasis and cancer, but the role of Axin1 remains elusive.

Methods: We assessed the role of Axin1 in normal intestinal homeostasis, with control, epithelial-specific, Axin1-knockout mice (Axin1) and Axin2-knockout mice.

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