[Off-label use of intravenous immunoglobulin g in a highly complex pediatric hospital in Argentina. A prospective observational study].

Introduction: The World Health Organization recommends prioritizing safe and effective drugs proven by clinical or epidemiological studies. However, in population groups with little research, a drug can be used for an indication or pharmaceutical form different from that approved by the regulatory agency (off-label), extrapolating data from studies in adults and exposing pediatric patients. to develop an Adverse Drug Reaction (ADR) due to safety considerations that have not been systematically studied.

[Validity and reproducibility of a food frequency questionnaire to assess lipid and phytochemical intake].

Background: epidemiological studies have been related food intake with the incidence of non-transmissible chronic diseases.

Objective: the purpose of the present study was to analyze the validity and reproducibility of a food frequency questionnaire (FFQ) aimed at assessing lipid and phytochemical intake.

Material And Methods: FFQ was administered to 45 people of both sexes, aged between 20 and 72 years old and resident in Cordoba, Argentina.

Beef consumption and fatty acids serum concentration: relationship with salivary gland tumors in Córdoba, Argentina.

Aim: The objective of the present study was to analyze beef consumption, conjugated linoleic acid (CLA) and n-3 fatty acid (FA) serum concentration and their relation to salivary gland tumors (SGT). A questionnaire on non-nutritional risk factors and a validated food frequency questionnaire were applied in 20 SGT and 20 control (Co) patients.

Materials And Methods: Food data were processed by the Interfood v.

Hearing and loud music exposure in a group of adolescents at the ages of 14-15 and retested at 17-18.

Young people expose themselves to potentially damaging loud sounds while leisure activities and noise induced hearing loss is diagnosed in increasing number of adolescents. Hearing and music exposure in a group of adolescents of a technical high school was assessed at the ages of: 14-15 (test) and 17-18 (retest). The aims of the current study were: (1) To compare the auditory function between test and retest; (2) to compare the musical exposure levels during recreational activities in test and retest; (3) to compare the auditory function with the musical exposure along time in a subgroup of adolescents.

Hearing and loud music exposure in 14-15 years old adolescents.

Adolescent exposure to loud music has become a social and health problem whose study demands a holistic approach. The aims of the current study are: (1) To detect early noise-induced hearing loss among adolescents and establish its relationship with their participation in musical recreational activities and (2) to determine sound immission levels in nightclubs and personal music players (PMPs). The participants consisted in 172 14-15 years old adolescents from a technical high school.

Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9,10-dimethyl-1,2-benzanthracene (DMBA).

The purpose of this study was to analyze the influence of diets varying in lipids and proteins on the histopathologic variety of murine salivary tumors induced by DMBA. 117 BALB/c mice were assigned to experiments one (E1: lipids, males) and two (E2: proteins, males and females), E1 comprising Soy oil (SO); Corn oil (CO, control); Fish oil (FO) and Olein (O) groups and E2, soy protein (SP) and casein (C) groups. Tumors were induced by DMBA and the animals were sacrificed at week 13- post-induction.

Program for the conservation and promotion of hearing among adolescents.

Purpose: We describe a program for the promotion of hearing conservation aimed at the adolescent population. The intent of our program is to (a) detect hearing disorders early, as well as to establish their relation to psychosocial and acoustic factors; (b) devise a follow-up procedure to study relevant variables; (c) evaluate the relation between hearing disorders and genetic factors, and (d) raise the social awareness of the effects of noise and its consequences.

Method: This program, designed to be carried out over a 7-year period, focuses on participants from technical schools in the city of Cordoba, Argentina.

[Proliferation and apoptosis in tongue epithelium of mice bearing salivary tumors induced by dimetilbenzantraceno (DMBA) and modulated by dietary lipids].

Introduction: According to the concept of field defects during the carcinogenesis process, excessive epithelial proliferation/apoptosis may exist in areas near tumors. Proliferation or apoptosis could be modified by dietary lipids.

Purpose: The present study was designed to analyze proliferation and apoptosis in tongue epithelium of mice fed diets based on different lipids followed by induction of salivary tumors with DMBA.

Recreational noise exposure and its effects on the hearing of adolescents. Part II: development of hearing disorders.

Part II, continuation of a previous paper, describes the significant hearing threshold shift found during the third year of the long-term study, which continued to be present in the fourth year, in a number of adolescents classified as Subgroup 2, who showed a higher mean HTL in the middle and especially in the high frequency ranges than the rest of the studied adolescents, classified as Subgroup 1. In both subgroups, the subjects showed high participation in recreational activities; nevertheless, the adolescents in Subgroup 2 showed higher participation in some of them in the last year of the study. From the beginning of the study, the mean HTL of the adolescents in Subgroup 2 was higher than the mean HTL of the adolescents in Subgroup 1.

Recreational noise exposure and its effects on the hearing of adolescents. Part I: an interdisciplinary long-term study.

This interdisciplinary long-term study examined the effects of recreational noise exposure on the hearing of adolescents. Boys and girls (aged 14-17 years) were examined during a four-year period. Audiological, psychosocial, and sound measurements were performed yearly to determine the hearing threshold level (HTL) of participants in the 250-16000 Hz range, their participation in recreational activities, and the sound levels at discos and through personal music player use.

Effects of soy oil on murine salivary tumorigenesis.

Dietary fat influences dimethylbenzanthracene (DMBA)-induced tumorigenesis of several organs, including the salivary glands. There is not enough evidence to suggest that soy oil could also affect growth of salivary tumors. The main purpose of this work therefore was to study the effects of dietary soy oil on macroscopic parameters of chemically induced murine salivary gland tumors.