Publications by authors named "Silvia Hulakova"
Article Synopsis
- The study investigates how the surfactant N,N-dimethyl-1-dodecanamine-N-oxide (DDAO) interacts with model membranes made of dioleoylphosphatidylcholine (DOPC) and DOPC-cholesterol (CHOL) at a neutral pH.
- Using methods like fluorescence probe leakage and turbidimetry, the researchers analyze pore formation in lipid bilayers and monitor changes in lipid aggregate size as DDAO concentration increases.
- The findings reveal that the partition coefficients of DDAO in DOPC and DOPC-CHOL membranes are similar and that replacing some DOPC with CHOL doesn't significantly affect the solubilization process, while the surf
The interaction of N,N-dimethyl-1-dodekanamine N-oxide (C12(CH3)2NO) with egg yolk phosphatidylcholine (EYPC) liposomes containing cholesterol (CHOL) was studied. The perturbation of CHOL-EYPC bilayers in unilamellar liposomes (ULL) was observed by the leakage of fluorescent probe calcein. Weak leakage is observed at low surfactant concentration cC12NO (minimal perturbation of the bilayer) followed by an intensive leakage at a middle cC12NO (creation of pores).
View Article and Find Full Text PDFBisphenol A differently inhibits CaV3.1, Ca V3.2 and Ca V3.3 calcium channels.
Naunyn Schmiedebergs Arch Pharmacol
February 2014
Bisphenol A (BPA) is a widespread environmental contaminant detected in urine of 93 % of investigated US population. Recent epidemiological studies found correlation between BPA exposure and diseases including cardiovascular and neuronal disorders. BPA targets include hormone receptors and voltage-dependent ion channels.
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