Publications by authors named "Silvia Grillini"
Article Synopsis
- - Cancer cells produce a protein called IF, which helps them survive during low oxygen conditions (ischemia) by inhibiting ATP synthase, important for energy production.
- - Researchers found that IF enhances the survival and growth of bone and colon cancer cells during stress conditions, through processes like mitophagy (recycling damaged mitochondria) and mitochondrial biogenesis (creating new mitochondria).
- - Reducing the activity of IF could be a potential treatment strategy for tumors that depend on oxygen-based energy production, as it may inhibit their growth under low oxygen conditions.
The pro-oncogenic protein IF does not contribute to the Warburg effect and is not regulated by PKA in cancer cells.
Biochim Biophys Acta Mol Basis Dis
January 2024
The endogenous inhibitor of mitochondrial FF-ATPase (ATP synthase), IF, has been shown to exert pro-oncogenic actions, including reprogramming of cellular energy metabolism (Warburg effect). The latter action of IF has been reported to be hampered by its PKA-dependent phosphorylation, but both reprogramming of metabolism and PKA-dependent phosphorylation are intensely debated. To clarify these critical issues, we prepared stably IF-silenced clones and compared their bioenergetics with that of the three parental IF-expressing cancer cell lines.
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