Publications by authors named "Silvia Di Nardo Stuppino"
Purpose: Recurrence of tuberculosis (TB) can be the consequence of relapse or exogenous reinfection. The study aimed to assess the factors associated with exogenous TB reinfection.
Methods: Prospective cohort study based on the TB database, maintained at the Division of Infectious Diseases, Luigi Sacco Hospital (Milan, Italy).
Article Synopsis
- The study investigates the timing and methods of treatment for HIV-positive patients during the early stages of infection, focusing on immunological and virological outcomes.
- A total of 25 patients were treated at the University of Milan and Turin between 2009 and 2014, receiving a combination of antiretroviral medications and monitored over 18 months for CD4 cell count and HIV-RNA levels.
- Results showed that patients treated during acute infection had a significantly higher increase in CD4 cells compared to those treated during recent infection, although overall virological success was similar between the two groups.
HIV drug resistance still represents a crucial problem in antiretroviral therapy. We report a case of a naive patient, harboring a CRF11-cpx virus, which showed drug resistance mutations in the reverse transcriptase. A drug resistance genotyping test was performed for the pol (protease, reverse transcriptase, and integrase) and V3 regions.
View Article and Find Full Text PDFBackground: Immunological non-responders (INRs) lacked CD4 increase despite HIV-viremia suppression on HAART and had an increased risk of disease progression. We assessed immune reconstitution profile upon intensification with maraviroc in INRs.
Methods: We designed a multi-centric, randomized, parallel, open label, phase 4 superiority trial.