Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected with .

Chagas disease is a major public health problem in Latin America. The mixed Th1/Th2 immune response is required against . Electrolyzed oxidizing water (EOW) has been shown to have germicidal efficacy.

DNA Vaccine Treatment in Dogs Experimentally Infected with .

Chagas disease is a chronic and potentially lethal disorder caused by the parasite , and an effective treatment has not been developed for chronic Chagas disease. The objective of this study was to determine the effectiveness of a therapeutic DNA vaccine containing genes in dogs with experimentally induced Chagas disease through clinical, pathological, and immunological analyses. Infection of Beagle dogs with the H8 strain was performed intraperitoneally with 3500 metacyclic trypomastigotes/kg body weight.

Prophylactic and therapeutic DNA vaccines against Chagas disease.

Chagas disease is a zoonosis caused by Trypanosoma cruzi in which the most affected organ is the heart. Conventional chemotherapy has a very low effectiveness; despite recent efforts, there is currently no better or more effective treatment available. DNA vaccines provide a new alternative for both prevention and treatment of a variety of infectious disorders, including Chagas disease.