Publications by authors named "Silvia De Barrio"
Short bowel syndrome related intestinal failure outcomes in Latin America: Insights from the RESTORE Registry.
JPEN J Parenter Enteral Nutr
November 2024
Article Synopsis
- Short bowel syndrome is a rare condition with limited existing data, prompting a registry study in Latin America focused on chronic intestinal failure, analyzing various patient and clinical factors from specialized centers.
- From May 2020 to July 2023, the study included 167 patients (115 adults and 52 children) across 20 centers, revealing key demographics, complications, and outcomes, with significant differences between adults and children in terms of etiology and follow-up results.
- The findings aim to enhance understanding of intestinal failure in Latin America, serving as both a data repository and an educational resource for healthcare teams, while striving for international recognition of regional health challenges.
Background: Short bowel syndrome (SBS) is considered a low prevalence disease. In Argentina, no registries are available on chronic intestinal failure (CIF) and SBS. This project was designed as the first national registry to report adult patients with this disease.
View Article and Find Full Text PDFBackground: Teduglutide, a semisynthetic analogue of glucagon-like peptide-2 (sGLP-2), increases intestinal absorption of fluids and nutrients, reducing the need for parenteral nutrition (PN). This report aims to describe our experience with sGLP-2 in a cohort of adult patients with short-bowel syndrome.
Methods: This is a prospective observational study on adult patients initially evaluated in our specialized intestinal rehabilitation program that received sGLP-2 from June 2014 to March 2020.
Objectives: Telomeres are important structures that are critical for maintaining chromosomal integrity and cell surveillance. The aim of this study was to analyze telomere length in patients with celiac disease (CD), a multifactorial disorder with a strong genetic component that exhibits genomic instability and cancer predisposition, particularly T-cell lymphomas.
Methods: Telomere length measured by telomere restriction fragments (TRF) was studied in small intestinal biopsy (SIB) samples and peripheral blood lymphocytes (PBL) from 20 untreated CD patients, distributed according to the clinical form as four asymptomatic, five monosymptomatic, and 11 polysymptomatic individuals.