[Impact of a primary care pharmacy unit on the optimization of pharmacological treatment of type 2 diabetic patients].

Objective: To evaluate the impact of a pharmaceutical intervention on treatment optimization in patients with type 2 diabetes mellitus.

Design: Before-after intervention study. SITE: Health centers of the Primary Care Department of Camp de Tarragona.

Design and validation of a predictive equation to estimate unbound valproic acid concentration.

Objectives: Total plasma levels of valproic acid (VPA) may mask an increased risk of adverse effects in hypoalbuminaemic patients since, in these patients, the free fraction is higher. The aim of this study is to analyse the relationship between plasma levels of total and free VPA (VPA) in hypoalbuminaemic patients and define an equation that allows the estimation of VPA concentration, as well as to validate the obtained equation.

Methods: This is a retrospective observational study conducted between January 2015 and January 2020.

[Catheter-related bloodstream infections in patients receiving central parenteral nutrition: prevalence, associated factors, and treatment].

Background: catheter-related infection is one of the complications of central parenteral nutrition treatment with the highest morbidity and mortality. Objectives: the primary endpoint of this study was to analyze the prevalence of bloodstream infection in patients with central parenteral nutrition. Secondary objectives included: a) an assessment of whether type of central catheter, duration of parenteral nutrition treatment, body mass index, or being admitted to the intensive care unit are factors associated with the development of bloodstream infection; b) an analysis of the therapeutic approach.