Publications by authors named "Silvia Caimi"
Numerous mammalian viruses are routinely analyzed in clinical diagnostic laboratories around the globe or serve as indispensable model systems in viral research. Potentially infectious viral entities are handled as blood, biopsies, or cell and tissue culture samples. Countless protocols describe methods for virus fixation and inactivation, yet for many, a formal proof of safety and completeness of inactivation remains to be shown.
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- The study investigates how lung epithelial cells and fibroblasts interact in a model that mimics idiopathic pulmonary fibrosis (IPF), revealing that the initial population of epithelial cells is diverse and includes some with a basal cell identity.
- Analysis showed that these cells and fibroblasts undergo different pro-fibrotic changes when cultured together, similar to those found in IPF patients' lungs.
- The research highlights NF-κB signaling as a key factor in this process, linking epithelial dysfunction to fibrosis and suggesting that blocking NF-κB could reduce harmful cell changes and inflammation.