Publications by authors named "Silvia C Galvan"
Background: Because the graphical presentation and analysis of motif distribution can provide insights for experimental hypothesis, PISMA aims at identifying motifs on DNA sequences, counting and showing them graphically. The motif length ranges from 2 to 10 bases, and the DNA sequences range up to 10 kb. The motif distribution is shown as a bar-code-like, as a gene-map-like, and as a transcript scheme.
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- Anal cancer is increasingly common among HIV+ individuals, particularly Men who have Sex with Men (MSM), despite treatments like HAART; high HPV infection rates among this group contribute to the issue.
- A study involving 324 HIV+ MSM in Mexico City revealed a staggering 86% prevalence of HPV, with 28% testing positive for HPV type 16, the most notable variant.
- The findings highlight the critical need for early detection and monitoring of HPV infections in HIV+ MSM to prevent anal neoplasia and cancer.
Background: The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal.
View Article and Find Full Text PDFVaccines against human papillomavirus: perspectives for controlling cervical cancer.
Expert Rev Vaccines
August 2007
Prophylactic vaccines against human papillomavirus (HPV) are on the market and will certainly reduce the incidence of genital warts and the risk of developing cervical cancer. In addition, they will contribute to reducing anal as well as head and neck cancers. However, effort should be made in the short term in order for these vaccines to have a real impact in the developing world, where almost 80% of cervical cancer cases occur.
View Article and Find Full Text PDFThe purpose of the present investigation, was to analyze the sequences of 16S ribosomal genes partially amplified from 17 isolated Giardia intestinalis obtained from faces of 13 children with intestinal pathology and four symptoms-free children with intestinal pathology. Analysis was made also with Giardia Portland-I and four Giardias isolated from dogs. Children ages in both groups ranged from six to twelve years.
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