[The role of fibroblast growth factor 19 in pathogenesis of bile acid diarrhea of the patients who underwent cholecystectomy].

Unlabelled: The occurrence of chronic diarrhea after cholecystectomy (CCY) has been described by many researchers. However, the main mechanisms of the development of this diarrhea are not fully understood. Supposed that dysregulation of the bile acids (ВA) absorption in the ileum is played a significant role in the development of diarrhea syndrome.

Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients.

Aim: In order to optimize the therapy, the functional state of the pancreas (P) and the peculiarities of metabolic activity of intestinal microbiota in adults with cystic fibrosis (CF) were assessed.

Materials And Methods: 14 CF patients (20-34 years, 7 men, 7 women) were enrolled. In 8 patients, the diagnosis was confirmed in the first year of life on the basis of clinical data, positive sweat test, 5 had genetic confirmation.

[Cholagenic diarrhea is a type of postcholescystectomy syndrome].

Aim: To study the role of biliary acids (BAs) in the pathogenesis of chronic diarrhea (CD) in patients undergoing cholecystectomy (CE).

Subjects And Methods: Twenty-five patients with post-CE diarrhea were examined. A comparison group consisted of 11 patients with diarrhea-predominant irritable bowel syndrome (IBS).

[Spontaneous bacterial peritonitis in liver cirrhosis: optimization issues of prevention and treatment].

Research of features of a current of a spontaneous bacterial peritonitis (SBP) allows to allocate close interrelation between SBP, system inflammatory reaction and a sepsis to consider SBP, as one of stages in evolution of the difficult infectious process caused, as a rule, by resident flora, developing at patients with decompensated liver cirrhosis (LC), which demands timely preventive maintenance and adequate antibacterial therapy. In the present work therapy and preventive maintenance SBP questions are considered. In article the extensive review of the data of the literature and own supervision by efficiency of treatment SBP also is presented.

[Multipurpose psyllium monotherapy in patients with diverticular disease].

The purpose of the research was the study of the prebiotic and hypolipidemic effects of 12-week treatment by psillium of patients with uncomplicated diverticular disease and hyperlipidemia. It has been established that the examined medicine has not any by-effects, normalizes intestinal motility and lowers a pain syndrome and flatulence. Prebiotic effect has proved by higher concentration of short-chain fatty acids in faeces and reduction of anaerobic index.

[The role of bile acids in the pathogenesis of chronic diarrhea].

Chronic diarrhea syndrome results from excess colonic bile acids. Fibroblast growth factor 19 (FGF19), produced in the ileum is response to bile acid absorption, regulates hepatic bile acids synthesis. Bile acid malabsorption can be found in various gastrointestinal conditions: the greatest losses bile acids with excrements were marked at patients with surgical resection of terminal ileum.

[Pre-and probiotics effectiveness in intestine microbiocenosis correction in patients after hemicolectomy].

Normal microflora plays a key role in ensuring and maintaining the health of human body. Currently, much attention is paid not only to rational, but the so-called optimal, or health nutrition, which includes individual selection of food, the most satisfying human needs for energy, plastic and regulatory components. The aim of our study was to evaluate the effectiveness of pre-and probiotics in correction of the intestine microbiocenosis, effect on the rate of the hyperendotoxemia and related functional changes in the liver and lipid metabolism.

[Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

Aim: To study the effect of the drug metadoxin on drug-metabolizing liver function in patients with liver lesions alcoholic etiology (ALD).

Materials And Methods: 36 patients with ALD, of which 16 patients were diagnosed with hepatitis, while 20 - with the liver cirrhosis. All the patients underwent biochemical blood analysis and the study of drug-metabolizing liver function according to the pharmacokinetics of antipyrine in saliva before and after treatment with metadoxin.

[Characteristics of the intestinal dysbiosis and endotoxemia after hemicolectomy].

Unlabelled: The normal intestinal microflora important for maintaining the optimum level of metabolic processes in the human body, the immune system, as well as to create a high colonization resistance against the pathogenic microbes. With aging, changes microbiocaenosis intestine, resulting in an increase in the total number of microbes in the gut and profound changes in the functional properties of microorganisms. Under physiological conditions, the main reservoir of endotoxin in the human body is the intestine.

[Biochemical characteristics of operating bile composition in different types of cholecystolithiasis].

With a view to predicting the outcomes of surgical treatment of cholelithiasis, depending on the composition of concretions by high performance liquid chromatography was studied lipid composition and the spectrum of the operating bile acids in 10 patients with bile pigment cholelithiasis, 15--with cholesterol cholelithiasis, 15--with a combination of cholesterol cholelithiasis, and scab forms cholesterosis gallbladder, 6--to polypous-mesh form cholesterosis gallbladder. As a control, use the operating bile 6 patients with adenomatous and fibro-adenomatous polyps of the gallbladder. Based on the results of the study was proved the need for correction of biliary insufficiency in patients operated on for cholesterin associated pathology of the gallbladder.

[Fecal excretion of short-chain fatty acids as a marker of the severity of ulcerative colitis].

Aim: to determine the fecal excretion of short-chain fatty acids (SCFA) in patients with active ulcerative colitis (UC) depending on the duration, activity, and severity of the disease.

Subjects And Methods: The study enrolled 53 patients, including 9 patients with proctosigmoiditis, 18 with left-sided colitis, and 26 with total colonic lesion. The total levels of metabolites, the concentrations of acetic, propionic, and butyric acids in the feces were measured by gas liquid chromatography.

[Pharmacokinetics of the proton pump inhibitors and psychological status in patients as factors that influence the efficiency of treatment of GERD with pantoprazole].

Was made an investigation of the effectiveness of pantoprazole (sanpraz, "SanFarma", India) at gastroesophageal reflux disease (GERD). 53 patients with GERD, including 20--with reflux esophagitis, received a daily dose of pantoprazole 40 mg to 28 days. To the 7 day of treatment heartburn was broke in 63.

[Combination therapy of arterial hypertension combined with liver pathology. The place of angiotensin converting enzyme inhibitors].

It is necessary to take into account presence of concomitant pathology while prescribing hypotensive therapy to patients with arterial hypertension (AH). Hydrophilic angiotensin converting enzyme inhibitors (ACEI) (lisinopril) which are not metabolized in the liver are theoretically safest in liver cirrhosis. We have examined and treated 180 patients with AH and assessed efficacy and tolerability of ACEI lisinopril and enalapril with consideration of their pharmacokinetic peculiarities in patients with various severity of involvement of the liver (steatosis or cirrhosis).

[Metabolic activity of intestinal microflora and its role in determination of nutritional support tactic after gastrectomy].

Nutrition recommendations in symptoms of postgastrectomy syndroms is very different. The calculation of regimen using the parenteral and enteral alimentation may be established in the control test of definition of fecal short-chain fatty acids and microflora in such patients. Probiotics attach to the intestinal wall and protect it from the attacks of pathologic microorganisms.

[Effect of zinc deficiency on effectiveness of the treatment of liver encephalopathy in patients with liver cirrhoses].

Zinc plays an important role in human physiologic processes being cofactor of many enzymes, it participates in numerous enzyme reactions. We have investigated 15 patients with liver cirrhoses of different etiology. With the rising of class of liver impairment and developing liver encephalopathy, level of zinc in blood drops.

[Pharmacokinetics of enalapril and metoprolol in hypertensive patients with hepatic pathology].

Aim: To examine characteristics of pharmacokinetics and pharmacodynamics of enalapril and metoprolol in hypertensive patients with gastrointestinal diseases to make relevant corrections in the treatment.

Material And Methods: The study included 36 hypertensive patients with steatosis, hepatic cirrhosis and ulcer. All the patients received metoprolol or enalapril.

[Clinical efficacy of enteral nutrition in inflammatory bowel diseases].

Undernutrition with weight loss, protein deficiency and specific deficiencies in vitamins, and trace elements are common in the acute phase of IBD. Anorexia, increased intestinal losses and systemic inflammation are the main causes of undernutrition. The relevance and extent of these deficiencies vary according to the site and extent of diseased intestine as well as disease activity.

[Hepatic lesion in patients with hepatocerebral dystrophy].

Aim: To study hepatic affection in hepatocerebral dystrophy (HCD) regarding clinical course and duration of the disease.

Material And Methods: The records on 63 HCD patients were studied retrospectively as to early clinical symptoms, onset dynamics, biochemical tests for hepatic function, morphological changes of the liver, immune and cytokine status, markers of hepatotropic viruses.

Results: Six variants of HCD course were identified: hepatic (24 patients), endocrine (17 patients), neurological (12 patients), psychoemotional (5 patients), hemolytic (3 patients), renal (1 patient).