MSH-5: malignant knee tumors timely detection index.

Background: Bone neoplasms are usually misdiagnosed causing a delay in their treatment. Bone neoplasms are usually confused with tendinitis, 31% of the cases corresponds to osteosarcomas and in 21% to Ewing's sarcomas.

Objective: To create a clinical-radiographic instrument of high diagnostic suspicion of knee bone neoplasms to prevent a delay in diagnosis.

Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1.

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood. Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. Nevertheless, the biology of the early progenitors that initiate the lymphoid program remains elusive.

[Characteristics of pain in oncologic disease of the knee].

Background: 10% of > 55-year-old adults suffer some kind of non-neoplastic knee pain and 75% of the musculoskeletal neoplastic disease develops in the knee.

Objective: to identify clinical characteristics of knee pain in neoplastic knee pathology.

Methods: after appropriate authorization of the Local Committee of Investigation and under informed consent, we made a crosssectional and a risk analysis study.

[Carpal bones and joints: roentgenographic measurements in 20- to 70-year-old healthy Mexicans].

Background: We undertook this study to identify normal radiographic anthropometry reference values of the carpal bones and joints in healthy Mexicans between 20 and 70 years old.

Methods: The study was comprised of 112 subjects without diabetes mellitus, rheumatoid arthritis, congenital and/or traumatic diseases in upper limbs. Roentgenograms in postero-anterior and lateral views of carpal bones and joints were performed using standardized techniques.

[Radiographic measurements of the wrist in healthy Mexicans].

Background: We undertook this study to determine normal radiographic measurements of the wrist in healthy Mexican persons.

Methods: We performed 112 roentgenograms of healthy wrists, 56 left wrists and 56 right wrists, in normal adults with Mexican parents and grandparents who were born in Mexico. We made two projections: frontal and lateral views of the wrist sing a standard technique.