Desquamation of corneal endothelial cells.

The process of wound healing of rabbit corneal endothelium involves the desquamation of significant numbers of endothelial cells, which may be found floating freely in the aqueous. It is suggested that this may be a general phenomenon of corneal endothelial wound healing, which accompanies the release of endothelial-cell attachments to Descemet's membrane and to neighboring cells during mitosis, allowing some of the cells to "fall of" into the anterior chamber. The possibility is discussed that such endothelial desquamation may contribute to had sensitization to he histocompatibility antigens of penetrating corneal grafts.

Psychometric properties of two measures of intrinsic motivation.

Howard's Maze Test and Maw and Maw's Which-to-Discuss Test were individually administered to 25 educable mentally retarded junior high school students. Although the internal consistency of both tests was acceptably high (.81 to .

An animal model for cicatrizing trachoma.

An animal model of cicatrizing trachoma was developed in cynomolgus monkeys. This model is consistent with our hypothesis that repeated ocular inoculation of Chlamydia trachomatis, BOUR strain, mimics the repeated reinfection that occurs naturally in endemic human trachoma. A chronic follicular conjunctivitis developed, and scarring later appeared in the superior tarsal conjunctiva.

Perpetuation of inflammation in uveitis.

A large number of different and predominantly non-specific mechanisms has evolved to amplify and to perpetuate inflammatory reactions. Which of these mechanisms enters into play depends upon the nature of the primary insult. Thus, pyogenic bacteria call forth polymorphonuclear leucocytes, which release enzymes and other pharmacologically active substances to enhance the response.

Repetitive idiopathic fetal hydrops.

Two cases of repetitive idiopathic fetal hydrops are reported, the second and third cases found in the literature. A normal pregnancy occurred in 1 of the patients following 2 successive pregnancies with fetal hydrops. Findings as well as diagnostic and therapeutic modalities are discussed.

Secretory component of IgA: a marker for differentiation of ocular epithelium.

Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma.

Convergent and discriminant validity of project PRIME's Guess Who?

Two forms of the Guess Who?, a peer-assessment instrument, were administered to 1,095 mildly handicapped learners and 143 teachers. Factor analysis of the student and teacher ratings yielded three factors--disruptive, bright, and dull--for both sets of data. Factor scores for the student and teacher forms were then intercorrelated in a multitrait-multimethod matrix, and the results established the convergent and discriminant validity of the instrument.

Relationship between classroom behavior and achievement of mildly mentally retarded children.

Although the relationship between classroom behavior and academic achievement is well established for nonretarded children, the nature of this relationship is not clear for retarded children. Behavioral observations of 177 students in classrooms for educable mentally retarded children and for educationally handicapped children were compared to their achievement scores. Although significant correlations were found between some categories of behavior and achievement in arithmetic, the general absence of strong correlations was noteworthy when compared to previous findings on nonretarded subjects.

Secretory immune system of rabbit ocular adnexa.

A distinct system of immunity in a variety of animals is located subjacent to epithelial surfaces and is typified by the predominance of immunoglobulin A (IgA) and secretory component (SC) in various external secretions, including tears. The present study examined normal rabbit lacrimal gland, conjunctiva, and cornea for the presence of immunoglobulin and SC. IgA-staining plasma cells predominated within lacrimal gland and conjunctival stroma, and SC was found in the epithelial cells of both these tissues but not within corneal epithelium.

Diffuse vaginal adenosis associated with imperforate hymen.

A case of imperforate hymen associated with adenosis of the proximal surface of the obstructing membrane and of the vaginal wall is reported. The histogenesis of vaginal adenosis coexisting with congenital obstructive lesions is discussed, and the importance of careful follow-up of the patients with this type of anomaly is emphasized.

Attitudinal versus ecological approaches to the characterization of institutional treatment environments.

The relational and discriminative properties of attitudinal and ecological measures of environments were examined within the context of a state hospital for mentally retarted clients. Three hypotheses were advanced, and the results gave substantial support for one of these and partial support for a second: (a) that the correlations between attitudinal and ecological measures should not differ significantly from zero, and (b) that differences among hospital treatment programs and living units should be reflected in ecological but not in attitudinal measures. However, the results did not provide clear confirmation for a third hypothesis: that differences among staff demographic characteristics and employment history should be reflected in attitudinal but not in ecological measures.

Characterization of prolactin binding by membrane preparations from rat liver.

Binding sites for prolactin were identified in a plasma-membrane-enriched fraction isolated from livers of mature female rats. 125I-labelled sheep prolactin prepared by the lactoperoxidase procedure retained the same molecular integrity and binding affinity as the native hormone at physiological pH. The receptors bound prolactin from different species, whereas non-lactogenic hormones were not bound.

Neurological complications of anticoagulation therapy: a neurologist's review.

Anticoagulant-induced bleeding may involve the brain, spinal cord, or peripheral nerves. It may occur with either coumarin or heparin anticoagulants, in the absence of trauma, and while prothrombin times, clotting times, or partial thromboplastin times are in accepted therapeutic ranges. Bleeding involving the brain occurs usually as a subdural hematoma, with intracerebral or subarachnoid hemorrhages occurring less frequently.