A New 19(10→9)Abeo-Euphane Triterpenoid with other Terpenoid Components from Trichilia dregeana Leaves and their NO Production Inhibitory Activities in LPS-Stimulated RAW264.7 Macrophages.

Trichilia dregeana Sond. (Meliaceae) is a plant used in traditional medicine to treat wounds. The anti-inflammatory potential of the ethyl acetate leaf extract and the presence of euphane-type triterpenes in this extract have recently been reported by our group.

Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes.

A new fructofuranoside glycerol, dryoptkirbioside (1), along with thirteen known compounds (2-14), was isolated from the MeOH extract of Dryopteris kirbi rhizomes by silica gel column chromatography, Sephadex LH-20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and chemical conversions. The hexane-soluble portion and the EAF fraction showed strong activities against lung (A549), breast (MCF-7), and cervical (HeLa) human cancer cell lines (IC values ranging from 4.

In vitro antiplasmodial activity and toxicological profile of extracts, fractions and chemical constituents of leaves and stem bark from Dacryodes edulis (Burseraceae).

Background: Dacryodes edulis is a plant that belongs to the Burseraceae family. It is widely used traditionally alone or in association with other plants in Cameroonian folk medicine to cure wounds, fever, headaches, and malaria. The aim of this work was to investigate the leaves and stem bark of D.

Foetidumins A-D, and other chemical constituents from Helichrysum foetidum (L.) Moench (Asteraceae) with antiparasite activity.

The phytochemical investigation of the MeOH and CHCl-MeOH (1:1) extracts from the flowers and twigs of Helichrysumfoetidum (L.) Moench (Asteraceae), which showed antileishmanial and antiplasmodial activities during the preliminary screening, led to the isolation of four undescribed compounds, including two ent-beyer-15-ene-type diterpenoids, foetidumins A (1) and B (2), one flavonoid, foetidumin C (3) and one chalcopyrone, foetidumin D (4). Additionally, fourteen known compounds comprising, two ent-beyer-15-ene-type diterpenoids (5-6), six flavonoids (7-12), two steroids (13-14), three triterpenoids (15-17), and one glyceryl monostearate (18) were also isolated.

Bioguided Fractionation and Isolation of an Antiplasmodial Saponin from the Roots of Nauclea xanthoxylon (A.Chev.) Aubrév. (Rubiaceae).

The root extract of Nauclea xanthoxylon (A.Chev.) Aubrév.

Cytotoxic potential of dihydrochalcones from and their semi-synthetic derivatives.

In the search of cytotoxic dihydrochalcones, this investigation led to the isolation of seven compounds (-) from and the preparation of eight derivatives (-). The cytotoxicity of samples was evaluated against lung (A549), breast (MCF-7), and cervical (HeLa) human cancer cells. The CHCl/MeOH extract of the aerial part had strong cytotoxicity against all cells [IC 11.

Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity.

Ripe figs, barks, and wood of Ficus vallis-choudae are used in traditional medicine against several conditions including nausea and malaria. However, its use is still to be scientifically documented and validated. Hence, the aim of the present work was to evaluate the antiplasmodial activity of the dichloromethane-methanol (DCM-MeOH (1:1)) crude extract, their hexane, dichloromethane, ethyl acetate, and methanoli fractions, as well as the isolated chemical constituents.

Alkenylbenzoquinones and other compounds from the fruit of exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities.

A phytochemical study of the methanol extract of the fruit of resulted in the isolation of a new alkenylbenzoquinone (), alongside the known compounds ()-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone (), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone (), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone (), (2,3,4,2',9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol (), monopalmitin (glyceryl palmitate) (), lupeol (), and 3--(-D-glucopyranoside)--sitosterol (). The structures of the compounds were established by the means of spectroscopic (1 D- and 2 D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities.

Manniindole, an indole derivative from the roots of and combined antischistosomal and enzymatic activities.

A new alkaloid, manniindole , together with four known compounds: aristolactam AII , aristolactam BII , piperolactam D and polycarpol were isolated from the crude extract EtOH-HO (8:2) of the roots of by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their anti-schistosomal activity against and for cytotoxicity activity against Huh7 and A549 cells.

Dewerin and gilbertionol two new secondary metabolites from the stem bark of (De Wild) J. Leonard.

The phytochemical investigation of the methanol extract of the stem bark of led to the isolation of two new secondary metabolites, 5,7-dihydroxy-4'-methoxyisoflavan-2,4-dione () and 23-hydroxy-2-tricosanone () along with 19 known compounds (). The structure of these compounds were established by interpretation of their spectral data, mainly HR-TOFESIMS, 1 D NMR (H, C and DEPT) and 2 D NMR (H-H COSY, HSQC, HMBC, and NOESY), and by comparison with those reported in the literature. The methanol extract and some isolates were screened for their antiradical, antibacterial, and inhibitory properties against acetylcholinesterase.

Constituents from with Anti- Type b Inhibitory Activities.

Three previously undescribed indole alkaloids, named latifolianine A () and latifoliaindoles A and B ( and ), along with 10 known compounds (-), were isolated from the heartwood of . Their structures were elucidated based on the analysis of their NMR and MS data. Latifolianine A () represents an unusual and unprecedented monoterpene indole alkaloid unit condensed with an ursane-type pentacyclic triterpenoid moiety.

Crotoliganfuran, a new clerodane-type furano-diterpenoid from Pierre ex Hutch.

The phytochemical investigation of the methanol extract of the bark of Pierre ex Hutch yielded a new clerodane-type diterpenoid crotoliganfuran () along with ten other compounds including 12-epicrotocorylifuran (), lupeol (), syringic acid (), aleuritolic acid acetate (), aleuritolic acid (), scopoletin (), geddic acid (), -sitosterol (), vanilic acid () and stigmastane-3,6-dione (). Their structures were established by spectroscopic means. The extract and all the isolates were screened for their inhibitory properties against butyrylcholinesterase and urease enzymes, respectively.

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance.

: Pathogenic yeasts resistance to current drugs emphasizes the need for new, safe, and cost-effective drugs. Also, new inhibitors are needed to control the effects of enzymes that are implicated in metabolic dysfunctions such as cancer, obesity, and epilepsy. The anti-yeast extract from (Combretaceae) was fractionated and the structures of the isolated compounds established by means of spectroscopic analysis and comparison with literature data.

Antifungal activity and acute toxicity of stem bark extracts of Drypetes gossweileri S. Moore-euphorbiaceae from Cameroon.

Drypetes gossweilleri S. Moore is a plant used in traditional medicine in Cameroon. The antifungal properties of its stem-bark crude extract and fractions DG(1), DG(2), DG(3), DG(4), DG(5), DG(6), DG(7), DG(8) and DG(9) were assayed by agar and broth dilution methods on solid and liquid media against C.

Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).

Two new sphingolipids mucusamide (1) and mucusoside (2) have been isolated from methanol soluble part of the stem bark of Ficus mucuso WELW., together with fifteen known secondary metabolites including cellobiosylsterol (3), β-sitosterol (4), stigmasterol (5), β-sitosterol 3-O-β-D-glucopyranoside (6), lupeol acetate (7), ursolic acid (8), procatechuic acid (9), 2-methyl-5,7-dihydroxychromone 8-C-β-D-glucoside (10), apigenin (11), (-)-epicatechin (12), (+)-catechin (13), N-benzoyl-L-phenylalanilol (14), α-acetylamino-phenylpropyl α-benzoylamino-phenylpropionate (15), asperphenamate (16) and bejaminamide (17). Structures of compounds 1 and 2 were elucidated by spectroscopic analysis and chemical methods.