Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case-control study.

Background: Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children.

Materials And Methods: All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population.

Associations of unsafe, unsupportive, and underdeveloped neighborhoods with atopic dermatitis in US children.

Background: Atopic dermatitis (AD) is influenced by multiple emotional and environmental factors. Yet, little is known about the impact of neighborhood environment characteristics on AD.

Objective: To determine the association of neighborhood characteristics with AD prevalence and severity in US children.

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.

Background: Little is known about the mental health (MH) hospitalization among patients with acne and rosacea.

Aims: To determine the MH disorders and cost burden associated with acne and rosacea.

Methods: Data were examined from the 2002-2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions).

Validation of inpatient international classification of disease ninth revision codes as predictors of venous leg ulcers.

Venous leg ulcers (VLU) comprise about 70% of lower leg wounds and cost more than 14 billion USD per year. Patients with VLU are often admitted to the hospital; however, epidemiological study of this important patient subset is challenged by lack of validated database search protocol. Five International Classification of Diseases (ICD) 9 codes were identified for their relationship with VLUs (454.

Atopic Dermatitis in US Adults: From Population to Health Care Utilization.

Background: Little is known about the predictors of health care utilization among US adults with atopic dermatitis (AD).

Objective: To determine the proportion and predictors of utilization in outpatient, urgent care, emergency department (ED), and hospital settings in US adults with AD.

Methods: A cross-sectional, population-based study of 3495 adults was performed.

Adult-Onset Atopic Dermatitis.

One in 4 adults with atopic dermatitis (AD) report adult-onset disease. Adult-onset AD appears to be associated with a different disease phenotype compared with childhood-onset AD. A broad differential diagnosis must be considered in a patient presenting with an adult-onset eczematous eruption, including allergic contact dermatitis, mycosis fungoides/cutaneous T-cell lymphoma, psoriasis, scabies, and so forth.

Parabens.

Parabens have been widely used as preservatives in the cosmetics, food, and pharmaceutical industries for more than 70 years. Monitoring for paraben allergy closely followed with studies reporting paraben testing in standard screening fashion as early as 1940. The frequency of sensitivity to this widely used biocide has remained low and remarkably stable for many decades despite extensive use and progressive expansion of utilization worldwide.

Atopic Dermatitis and Hospitalization for Mental Health Disorders in the United States.

Little is known about mental health (MH) emergencies in atopic dermatitis (AD) and their financial burden. We sought to determine hospitalization rates and costs of MH disorders in AD patients. We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, containing a representative 20% sample of US hospitalizations.

Health Utility Scores of Atopic Dermatitis in US Adults.

Background: The impact of atopic dermatitis (AD) on health-related quality of life and health utility in the US adult population is not well established.

Objective: To determine the health utilities and quality-adjusted life-years (QALYs) lost in adults with AD versus without AD in the US population.

Methods: A cross-sectional, population-based study of 3495 adults was performed.

Association between atopic dermatitis and extracutaneous bacterial and mycobacterial infections: A systematic review and meta-analysis.

Background: Atopic dermatitis (AD) is associated with increased bacterial colonization and infection of skin and multiple risk factors for extracutaneous infections. However, previous studies found conflicting results about whether AD is associated with increased extracutaneous infections.

Objective: To determine whether extracutaneous bacterial and mycobacterial infections are increased in AD.

Inpatient burden of juvenile dermatomyositis among children in the United States.

Background: Juvenile dermatomyositis (JDM) is a rare autoimmune disease that causes significant morbidity and quality of life impairment. Little is known about the inpatient burden of JDM in the US. Our goal was to determine the prevalence and risk factors for hospitalization with juvenile dermatomyositis and assess inpatient burden of JDM.

Associations of Nickel Co-Reactions and Metal Polysensitization in Adults.

Background: Allergic contact dermatitis to metals is a significant clinical and public health problem. Little is known about the determinants of polysensitization to metals.

Objective: The aim of the study was to determine the frequency and predictors of nickel co-reactions and metal polysensitization.

Association between hidradenitis suppurativa and hospitalization for psychiatric disorders: a cross-sectional analysis of the National Inpatient Sample.

Background: Hidradenitis suppurativa (HS) is associated with pain, disfigurement, psychosocial distress and poor quality of life, all of which may lead to a higher likelihood of mental health (MH) disorders. However, little is known about the MH comorbidities of HS.

Objectives: To determine the MH disorders and cost burden associated with HS.

Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population.

Population-based estimates on the prevalence of atopic dermatitis in adults vary widely. The objectives of this study were to determine the prevalence of atopic dermatitis in the population of the United States, the distribution of disease severity, and its impact on health-related quality of life. Among 1,278 participating adults, the prevalence (95% confidence interval) of atopic dermatitis was 7.

Exploring the association between parental psychiatric disease and childhood atopic dermatitis: a matched case-control study.

Background: Maternal prenatal psychiatric disease has been identified as a possible risk factor for atopic dermatitis development in her children. We quantified the associations between maternal and paternal psychiatric disease and the development of atopic dermatitis in their offspring using nationwide registries.

Methods: All children in Denmark born between 1 January 1996 and 31 December 2011 who developed atopic dermatitis prior to their fifth birthday were identified and individually matched 1:10 with controls from the general population and with children receiving care in a similar ambulatory/hospital setting.

Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families.

Introduction: The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at http://www.clinicaltrials.gov ).

Association between atopic dermatitis and autoimmune disorders in US adults and children: A cross-sectional study.

Background: Little is known about the risk and predictors of autoimmune diseases in children and adults.

Objective: To determine the prevalence, predictors, and excess costs of autoimmune disease in atopic dermatitis (AD) patients.

Methods: Cross-sectional study of the 2002-2012 National Inpatient Sample, which includes a ∼20% sample of all US hospitalizations (n = 87,053,155 adults and children).

A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.

Background: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.

Objective: To determine the prevalences of AD characteristics and differences by region and age.

Methods: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics.

Measurement properties of three assessments of burden used in atopic dermatitis in adults.

Background: Standardized quality-of-life (QoL) assessments can provide important and clinically relevant information. There is currently a lack of standardization in QoL assessments used in atopic dermatitis (AD).

Objectives: To determine the content validity, construct validity, internal consistency, differential reporting, responsiveness, floor or ceiling effects and feasibility of the Dermatology Life Quality Index (DLQI), Itchy Quality of Life (ItchyQoL) and 5-dimensions (5-D) itch scales for assessing burden of AD in adults and to compare their performance.

Association of vitiligo with hospitalization for mental health disorders in US adults.

Background: Vitiligo has a complex bidirectional relationship with mental health (MH) disturbances. However, little is known about the relationship between vitiligo and MH emergencies.

Objective: To examine the associations of vitiligo and MH hospitalizations in the United States.

Sleep Disturbance and Sleep-Related Impairment in Adults With Atopic Dermatitis: A Cross-sectional Study.

Background: Little is known about the impact of sleep disturbances (SD) or sleep-related impairment (SRI) in adults with AD or their relationship with severity of AD and itch and other predictors.

Objective: The aim of this study was to determine the relationship between AD severity, SD, and SRI.

Methods: We conducted a prospective online questionnaire-based study of 287 adults with AD, including assessment of AD severity by Patient-Oriented Eczema Measure, self-reported global AD severity, Self-Assessed Eczema Area and Severity Index and visual analog scale-itch, Patient-Reported Outcome Measurement Information System SD and SRI individual items, and T scores.

Patient-reported outcomes and quality of life measures in atopic dermatitis.

Atopic dermatitis (AD) is a complex and heterogeneous disorder with a profound symptom burden and harmful impact on multiple domains of quality of life (QOL). Many different patient-reported outcome (PRO) measures exist to assess clinical manifestations and QOL impairment in AD, but none comprehensively assess all aspects of the disease. This review addresses the PRO and QOL measures currently used in AD and their properties, strengths, weaknesses, and feasibility for assessing AD in randomized controlled trials and clinical practice.