Association of taste receptor gene polymorphisms with dental caries.

This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children's systemic health, characteristics, oral hygiene habits, and diet.

Assessing the Association between Dental Caries and Nutritional Status in Children from the Brazilian State of Amazonas.

Aim: To evaluate the association between dental caries and nutritional status in a group of Brazilian schoolchildren, from Manaus. The studied population consisted of 197 students (10-12-year-olds) from public schools at Manaus, Amazonas, Brazil.

Materials And Methods: A clinical examination was carried out and the decay-missing-filled-teeth index for primary and permanent teeth (dmft and DMFT) was used to evaluate dental caries.

MMP13 Contributes to Dental Caries Associated with Developmental Defects of Enamel.

The aim of this study was to investigate the association between genetic polymorphisms in MMP8, MMP13, and MMP20 with caries experience and developmental defects of enamel (DDE) in children from the Amazon region of Brazil. Den tal caries and DDE data were collected through clinical examination from 216 children. Genomic DNA was extracted from saliva, and genotyping of selected polymorphisms in MMP8 (rs17099443 and rs3765620), MMP13 (rs478927 and rs2252070), and MMP20 (rs1784418) was performed using TaqMan chemistry and endpoint analysis.

Timing of Permanent Tooth Emergence is Associated with Overweight/Obesity in Children from the Amazon Region.

The aim of this study was to evaluate the association between timing of permanent tooth emergence with overweight and obesity in children from Brazilian Amazon region. The studied population consisted of 192 children, 09 to 12 year-old, from public schools at Manaus, Amazonas-Brazil. Clinical examination was performed and the tooth emergence was evaluated according to the number of permanent erupted teeth.

Oestrogen receptor alpha, growth hormone receptor, and developmental defect of enamel.

Background: Oestrogen (ES) and growth hormone (GH) are hormones that may have a role in caries aetiology and developmental defects of enamel (DDE) since their receptors (ERs and GHR) are expressed during amelogenesis.

Aim: To evaluate whether genetic polymorphisms in the genes that codify the ERα (ESR1) and GHR are associated with caries experience and DDE in children.

Design: Two hundred and sixteen children of both genders, aged 9-12 years, were examined and classified according to caries and DDE phenotype.