Publications by authors named "Silvana da Silva Sapelli"
Can J Physiol Pharmacol
September 2018
Article Synopsis
- The study evaluated apoptosis in the parotid glands of Wistar rats treated with midazolam, with some groups also receiving pilocarpine.
- Results indicated that rats treated with midazolam alone exhibited a significantly higher apoptotic index compared to control groups treated with saline.
- The addition of pilocarpine reduced the apoptotic effects caused by midazolam, suggesting it may offer some protective benefits against cell death in the glands.
Front Pharmacol
July 2016
Article Synopsis
- Benzodiazepines (BZDs) can lead to decreased saliva production by affecting the structure of parotid glands, resulting in changes in cell types like acinar, ductal, and myoepithelial cells.
- The study involved 90 male Wistar rats, with different groups receiving varying treatments of BZDs or pilocarpine over 30 to 60 days to observe effects on cell expression.
- Results indicated that lorazepam increased calponin expression in myoepithelial cells, while midazolam combined with pilocarpine enhanced cell proliferation but reduced calponin levels, suggesting that myoepithelial cells might be particularly affected by BZDs.
