Publications by authors named "Silvana Vigil"
Article Synopsis
- Isoflavones, specifically bis-pyrano prenyl isoflavone from Polygala molluginifolia, show promise in improving glucose homeostasis in hyperglycemic rats by enhancing glucose tolerance and increasing liver glycogen.
- The isoflavone acts by inhibiting maltase activity and stimulating the secretion of GLP-1 and insulin, exhibiting effects similar to the diabetic medication sitagliptin.
- Additionally, it promotes calcium influx in intestinal cells through various signaling pathways, contributing to GLP-1 secretion and potentially reducing protein glycation for long-term benefits.
Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of biomolecules and has been associated with inflammatory diseases. The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM) increased the MPO activity in vitro (of isolated enzyme and in isolated cells after animal treatment) and in vivo assays. MPO-induction may represent a good model system to investigate the molecular and cellular mechanisms of oxidative cell injury induced by activated neutrophils, and the interactions between damaging species involved in the respiratory burst.
View Article and Find Full Text PDFBackground: This study examined the effect of weight loss on energy intake, vitamin C, E, beta-carotene (diet/blood), reduced glutathione (GSH), C-reactive protein (CRP), thiobarbituric acid reactive substances (TBARS), catalase, and myeloperoxidase, in patients with Roux-en-Y bypass gastroplasty.
Methods: Prospective clinical study with control (C) and bariatric (B) groups (n = 20 each). Age was 38.
The aim of this study was to investigate the anti-inflammatory efficacy of an aqueous extract (AE), and its butanolic (BuOH) and aqueous residual (AR) fractions, derived from the rhizome of Solidago chilensis in inflammation caused by carrageenan in mice. Solidago chilensis Meyen rhizome was extracted using hot water at 90 degrees C under infusion. The extract was filtered and lyophilized.
View Article and Find Full Text PDFBackground: Tacrolimus (Tac) is a macrolide immunosuppressant drug isolated from Streptomyces tsukubaensis, widely used in organ transplantation.
Objective: This study examined the effect of tacrolimus administered by oral route (p.o.