Publications by authors named "Silvana Spindola"
Article Synopsis
- - Mozambique has a high prevalence of tuberculosis (TB), particularly with multidrug-resistant strains and co-infection with HIV, making it a significant public health concern.
- - A study analyzed 79 suspected drug-resistant TB strains from Beira using spoligotyping and compared them to existing data, revealing four main clades of M. tuberculosis—Latin-American-Mediterranean, East-African-Indian, Beijing, and T.
- - The findings indicate that the population genetic structure of M. tuberculosis in Beira is consistent with that found throughout Mozambique, highlighting a shared genetic background of the bacteria in the region.
Molecular genotyping has shown Mycobacterium tuberculosis lineages to be geographically restricted and associated with distinct ethnic populations. Whether tuberculosis (TB) caused by some M. tuberculosis lineages can present with a differential clinical spectrum is controversial because of very limited clinical data.
View Article and Find Full Text PDFApplication of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family.
J Clin Microbiol
April 2008
The Latin American-Mediterranean (LAM) family of Mycobacterium tuberculosis is believed to be the cause of approximately 15% of tuberculosis cases worldwide. Previously, we defined a prevalent sublineage of the LAM family in Brazil by a single characteristic genomic deletion designated RD(Rio). Using the Brazilian strains, we pinpoint an Ag85C(103) single nucleotide polymorphism (SNP) (screened by restriction fragment length polymorphism [RFLP] analysis) that correctly identified all LAM family strains.
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