Publications by authors named "Silvana Maglio"
Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas.
View Article and Find Full Text PDFWe retrospectively analyzed the findings of a prospective cohort of 75 children referred for thyroid nodules between 2008 and 2013. Prevalence of papillary differentiated thyroid carcinoma was 18.7%.
View Article and Find Full Text PDFThoracic masses in neonates usually respond to congenital anomalies of the respiratory system. They comprise a large number of diseases that can compromise the development of larynx, trachea, bronchi, pulmonary parenchyma and diaphragm or chest wall. Diagnosis is carried out during prenatal period by ultrasound in most cases.
View Article and Find Full Text PDFDifferentiated thyroid carcinoma: presentation and follow-up in children and adolescents.
J Pediatr Endocrinol Metab
January 2012
Article Synopsis
- The study analyzed 45 pediatric patients diagnosed with differentiated thyroid carcinoma (DTC) over a 20-year period, revealing a predominance of papillary type and common presentation as solitary nodules or in conjunction with cervical adenopathy.
- Most patients underwent complete thyroid removal and treatment with radioactive iodine, with a follow-up showing a 75% disease-free survival rate over 5 years, despite 11% experiencing recurrences.
- The findings indicated an aggressive nature of pediatric DTC at diagnosis, with higher preoperative TSH levels linked to more advanced disease, highlighting the need for further research on associated conditions like chronic lymphocytic thyroiditis (CLT).
Context: Epstein-Barr virus (EBV) has been classically associated with 3 malignancies, Burkitt lymphoma, B-cell lymphoproliferative syndromes, and nasopharyngeal carcinoma, and more recently with Hodgkin disease, T-cell lymphomas, and gastric and breast carcinomas, as well as with leiomyosarcoma and leiomyoma associated with immunosuppression.
Objective: To compare EBV expression in Argentine tumor samples with those reported elsewhere, we analyzed EBV expression in an Argentine pediatric population with non-Hodgkin lymphoma and correlated these results with clinical course and outcome.
Methods: We studied EBV presence by latent membrane protein-1 protein labeling by immunohistochemistry, by in situ hybridization, and by polymerase chain reaction for Epstein-Barr-encoded RNAs (EBERs) in formalin-fixed and paraffin-embedded non-Hodgkin lymphoma tissue samples (collected retrospectively) from 32 pediatric patients at Ricardo Gutiérrez Children's Hospital from 1993 to 2000.