Publications by authors named "Silvana Gionco"
Article Synopsis
- Regulation of iron (Fe) levels is crucial for processes like red blood cell production (erythropoiesis) and to prevent toxicity, with hepcidin being the key regulatory peptide produced by the liver that controls Fe absorption and release.
- Erythropoietin (Epo), a glycoprotein that supports red blood cell development, directly inhibits hepcidin expression in liver cells (HepG2), resulting in lowered intracellular Fe levels through the activation of specific signaling pathways, particularly JAK2 and PI3K/AKT/mTOR.
- Epo's effects on hepcidin also involve modulation of transcription factors, decreasing the activity of C/EBP-α while enhancing the inhibitory
Homocysteine and its cyclic ester homocysteine thiolactone (HTL) have been involved in the detrimental consequences associated to hyperhomocysteinemia, an independent risk factor for vascular diseases. HTL reacts with protein lysine residues in a process named N-homocysteinylation. The aim of our study was to evaluate the in vitro effects of HTL on the fibrinogen through electrophoretic methods.
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