Publications by authors named "Silvana D Ortiz"
Article Synopsis
- Growth hormone (GH) is crucial for bone growth, but excess levels from pituitary adenomas lead to severe joint issues, particularly in acromegaly patients.
- A study using wild-type and bovine GH transgenic mice showed that excess GH causes increased sensitivity to pain, reduced bone density, and significant deterioration of knee joint tissues.
- The findings indicate that the inflammatory response from excess GH affects all joint tissues differently than osteoarthritis, suggesting treatment should focus on reducing abnormal cartilage growth and inflammation.
