Publications by authors named "Siluo Wu"
Osteoarthritis (OA) is a common chronic degenerative disease which is characterized by the disruption of articular cartilage. Syringic acid (SA) is a phenolic compound with anti-inflammatory, antioxidant, and other effects including promoting osteogenesis. However, the effect of SA on OA has not yet been reported.
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- - Osteoporosis is a chronic bone disease characterized by low bone density and structural damage; Ginsenoside Compound-K (CK) has shown promise in promoting bone health and healing fractures.
- - This study investigates CK's effect on osteoclastogenesis and bone loss related to ovariectomy-induced osteoporosis, finding that CK inhibits cell differentiation and reduces oxidative stress.
- - The findings suggest that CK not only prevents osteoclast activity but also protects against bone loss in a living organism by targeting and inhibiting the NF-κB signaling pathway.
Fractures have an extraordinarily negative impact on an individual's quality of life and functional status, particularly delayed or non-union fractures. Osteogenesis and angiogenesis are closely related to bone growth and regeneration, and bone modeling and remodeling. Recently Chinese medicine has been extensively studied to promote osteogenic differentiation in MSCs.
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