Highly Efficient Blue Light-Emitting Diodes Enabled by Gradient Core/Shell-Structured Perovskite Quantum Dots.

Room temperature (RT) synthesized mixed bromine and chlorine CsPbBrCl perovskite quantum dots (Pe-QDs) offer notable advantages for blue quantum dot light-emitting diodes (QLEDs), such as cost-effective processing and narrow luminescence peaks. However, the efficiency of blue QLEDs using these RT-synthesized QDs has been limited by inferior crystallinity and deep defect presence. In this study, we demonstrate a precise approach to constructing high-quality gradient core-shell (CS) structures of CsPbBrCl QD through anion exchange.

Underwater moving target detection using online robust principal component analysis and multimodal anomaly detection.

In shallow water, reverberation complicates the detection of low-intensity, variable-echo moving targets, such as divers. Traditional methods often fail to distinguish these targets from reverberation, and data-driven methods are constrained by the limited data on intruding targets. This paper introduces the online robust principal component analysis and multimodal anomaly detection (ORMAD) method to address these challenges.

Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.

Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor.

Enhancing Water Electrolysis through Interfacial Design of Nickel Foam.

Water electrolysis recognizes nickel foam (NF) as an effective current collector due to its excellent conductivity. However, recent studies highlighted NF's effect on the efficacy of various electrocatalytic reactions, primarily due to the presence of electroactive chemical species at its interface. In contrast, numerous reports suggested that NF has a negligible impact on overall electrocatalytic activity.

Ferroelectric/Electric-Double-Layer-Modulated Synaptic Thin Film Transistors toward an Artificial Tactile Perception System.

Tactile sensation and recognition in the human brain are indispensable for interaction between the human body and the surrounding environment. It is quite significant for intelligent robots to simulate human perception and decision-making functions in a more human-like way to perform complex tasks. A combination of tactile piezoelectric sensors with neuromorphic transistors provides an alternative way to achieve perception and cognition functions for intelligent robots in human-machine interaction scenarios.

Self-Assembly of Amorphous 2D Polymer Nanodiscs with Tuneable Size, pH-Responsive Degradation and Controlled Drug Release.

Amphiphilic bottlebrush block copolymers (BBCs) with tadpole-like, coil-rod architecture can be used to self-assemble into functional polymer nanodiscs directly in water. The hydrophobic segments of the BBC were tuned via the ratio of ethoxy-ethyl glycidyl ether (EE) to tetrahydropyranyl glycidyl ether (TP) within the grafted polymer sidechains. In turn, this variation controlled the sizes, pH-responsiveness, and drug loading capacity of the self-assembled nanodiscs.

Prognostic Significance of Computed Tomography-Derived Fractional Flow Reserve for Long-Term Outcomes in Individuals With Coronary Artery Disease.

Background: Data on the predictive value of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) for long-term outcomes are limited.

Methods And Results: A retrospective pooled analysis of individual patient data was performed. Deep-learning-based CT-FFR was calculated.

The formation, maintenance, and loss of island biodiversity.

Due to the unique geographical features of large numbers, isolated by water and diverse formation histories, islands have become natural laboratories for ecological and evolutionary research. Islands have a high proportion of endemic species and disharmony in representing the species compared with that in the continent, which provides a good opportunity to explore the formation of island biodiversity. In this review, we focuse on island ecosystems and describes the progress of research in island biogeography in recent years from three aspects: formation, maintenance, and loss of island biodiversity.

Molecular Mechanisms of circKIF4A in Breast Cancer Progression.

Aim: Breast cancer (BC) is the most frequently diagnosed malignancy worldwide, necessitating continued research into its molecular mechanisms. Circular RNAs (circRNAs) are increasingly recognized for their role in various cancers, including BC. This study explores the role of circRNA kinesin family member 4A (circKIF4A) in BC progression and its underlying molecular mechanisms.

Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway.

Pancreatic cancer is an aggressive tumor, which is often associated with a poor clinical prognosis and resistance to conventional chemotherapy. Therefore, there is a need to identify new therapeutic markers for pancreatic cancer. Although KIN17 is a highly expressed DNA‑ and RNA‑binding protein in a number of types of human cancer, its role in pancreatic cancer development, especially in relation to progression, is currently unknown.

Carbon Storage Response to Land Use/Land Cover Changes and SSP-RCP Scenarios Simulation: A Case Study in Yunnan Province, China.

Changes in terrestrial ecosystem carbon storage (CS) affect the global carbon cycle, thereby influencing global climate change. Land use/land cover (LULC) shifts are key drivers of CS changes, making it crucial to predict their impact on CS for low-carbon development. Most studies model future LULC by adjusting change proportions, leading to overly subjective simulations.

Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and intertumoral heterogeneity.

Chromothripsis, a hallmark of cancer, is characterized by extensive and localized DNA rearrangements involving one or a few chromosomes. However, its genome-wide frequency and characteristics in urothelial carcinoma (UC) remain largely unknown. Here, by analyzing single-regional and multi-regional whole-genome sequencing (WGS), we present the chromothripsis blueprint in 488 UC patients.

Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data.

Background: The relationship between dietary vitamin E intake and the risk of cardiovascular diseases, as well as cardiovascular and all-cause mortality, remains inconclusive. This study aimed to investigate these associations in a large, representative sample of the U.S.

Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.

The global phenomenon of cyanobacterial bloom pollution is spreading globally due to climate change and eutrophication. It is well established that harmful cyanobacteria produce a wide range of toxins including microcystin-LR (MC-LR), a cyclic heptapeptide toxin known to damage various organs. The intestinal tract is the main site of MC-LR absorption and one of the targets susceptible to toxicity.

AENK ameliorates cognitive impairment and prevents Tau hyperphosphorylation through inhibiting AEP-mediated cleavage of SET in rats with ischemic stroke.

Brain damage induced by ischemia promotes the development of cognitive dysfunction, thus increasing the risk of dementia such as Alzheimer's disease (AD). Studies indicate that cellular acidification-triggered activation of asparagine endopeptidase (AEP) plays a key role in ischemic brain injury, through multiple molecular pathways, including cleavage of its substrates such as SET (inhibitor 2 of PP2A, I ) and Tau. However, whether direct targeting AEP can effectively prevent post-stroke cognitive impairment (PSCI) remains unanswered.

Activation and memory of the heatshock response is mediated by Prion-like domains of sensory HSFs in Arabidopsis.

Plants are able to sense and remember heat stress. An initial priming heat stress enables plants to acclimate so that they are able to survive a subsequent higher temperature. The heatshock transcription factors (HSFs) play a crucial role in this process, but the mechanisms by which plants sense heat stress are not well understood.

sly-miR408b Targets a Plastocyanin-Like Protein to Regulate Mycorrhizal Symbiosis in Tomato.

Symbiosis between arbuscular mycorrhizal fungi and plants plays a crucial role in nutrient acquisition and stress resistance for terrestrial plants. microRNAs have been reported to participate in the regulation of mycorrhizal symbiosis by controlling the expression of their target genes. Herein, we found that sly-miR408b was significantly downregulated in response to mycorrhizal colonisation.

Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy.

Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune response. Metabolic dysregulation creates an immunosuppressive TME, impairing the antitumor immune response.

Effects of the Oral Health Promotion Program on oral health and oral microbiota changes in diabetic elderly individuals: a quasi-experimental study.

Background: Diabetes with its highly prevalence has become a major contributor to the burden of health care costs worldwide. Recent unequivocal evidence has revealed a bidirectional link between oral health and diabetes. In this study, the effects of the Oral Health Promotion Program (OHPP) on oral hygiene, oral health-related quality of life and glycated haemoglobin (HbA1c) levels in diabetic elderly were examined.

Quantifying intratumoral heterogeneity within sub-regions to predict high-grade patterns in clinical stage I solid lung adenocarcinoma.

Background: This study aims to quantify intratumoral heterogeneity (ITH) using preoperative CT image and evaluate its ability to predict pathological high-grade patterns, specifically micropapillary and/or solid components (MP/S), in patients diagnosed with clinical stage I solid lung adenocarcinoma (LADC).

Methods: In this retrospective study, we enrolled 457 patients who were postoperatively diagnosed with clinical stage I solid LADC from two medical centers, assigning them to either a training set (n = 304) or a test set (n = 153). Sub-regions within the tumor were identified using the K-means method.

CK19 protein expression: the best cutoff value on the prognosis and the prognosis model of hepatocellular carcinoma.

Background And Objective: In clinical practice, CK19 can be an important predictor for the prognosis of HCC. Due to the high incidence and mortality rates of HCC, more effective and practical prognostic prediction models need to be developed urgently.

Methods: A total of 1,168 HCC patients, who underwent radical surgery at the Guangxi Medical University Cancer Hospital, between January 2014 and July 2019, were recruited, and their clinicopathological data were collected.

High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy.

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder associated with pregnancy and is usually diagnosed based on high serum bile acid. However, the pathogenesis of ICP is unclear. Ferroptosis has been reported as an iron-dependent mechanism of cell death.

Integrated analysis of single-cell and bulk-RNA sequencing for the cellular senescence in prognosis of lung adenocarcinoma.

Non-small cell lung cancer (NSCLC), half of which are lung adenocarcinoma (LUAD), is one of the most widely spread cancers in the world. Telomerase, which maintains telomere length and chromosomal integrity, enables cancer cells to avoid replicative senescence. When telomerase is inhibited, cancer cells' senescence began, preventing them from growing indefinitely.

Sensitive and selective colorimetric detection of thiophanate-methyl based on a novel Ru-FeO nanozyme with enhanced peroxidase-like activity.

A novel Ru-FeO nanozyme with enhanced peroxidase-like (POD-like) activity was synthesized through a hydrothermal method. Ru-FeO nanozyme was effectively utilized for the detection of thiophanate-methyl (TM) using a colorimetric technique. The POD-like activity of Ru-FeO was found to be superior compared to FeO, Rh-FeO, and Pd-FeO.