Publications by authors named "Silu Chen"
To improve the settling time for high-speed point-to-point motion, a piecewise-model feedforward controller is introduced which utilizes multiple inverse sub-models with bumpless transfer between them. As the transfer function of this bumpless feedforward controller is non-commutative and non-invertible, a set of special perturbation and reference inputs are designed to extract the signals required for computing the gradient of the cost function. In this way, the optimal parameters within different motion phases are found within an integrated process.
View Article and Find Full Text PDFThe KangDuo Surgical Robot-1500 (KD-SR-1500) is a newly developed surgical robot. We aim to evaluate the feasibility and efficiency of the KD-SR-1500 system for robot-assisted radical prostatectomy (RARP). This prospective, multicenter, single-arm clinical study was conducted among 18-75-year-old patients with suspected T1-2N0M0 prostate cancer scheduled for RARP.
View Article and Find Full Text PDFBackground: Pineal region tumors encompass a wide range of pathologies, presenting challenges in pre-surgical characterization and exhibiting variable prognostic outcomes across different tumor types. This study aims to identify key imaging features from pre-treatment magnetic resonance imaging (MRI) of pineal region tumors to aid in prognostic analysis.
Methods: We retrospectively enrolled 33 patients with pineal region tumors who underwent pre-treatment imaging at the Seventh Medical Center of the Chinese PLA General Hospital between January 2010 and June 2023.
The structure of soft tissues is often destroyed by injury and aging. Injectable fillers eliminate the need for surgery and enhance repair. Hyaluronic acid-based hydrogels are commonly employed for their effectiveness and biocompatibility.
View Article and Find Full Text PDFBackground: The aim of this study was to report our technique and medium-term outcomes of modified robot-assisted laparoscopic dismembered pyeloplasty (RALDP) in the Lithotomy Trendelenburg position for treating adult ureteropelvic junction obstruction (UPJO) with horseshoe kidney (HSK).
Methods: Between March 2021 and March 2023, 11 adult patients with UPJO and HSK underwent modified RALDP in the lithotomy Trendelenburg position. Patient demographic characteristics, perioperative parameters, and follow-up outcomes were collected prospectively and analyzed.
Characterizing PANoptosis gene signature in prognosis and chemosensitivity of colorectal cancer.
J Gastrointest Oncol
October 2024
Background: PANoptosis is a cell death pathway involved in pyroptosis, apoptosis and necrosis, and plays a key role in the development of malignant tumors. However, the molecular signature of PANoptosis in colorectal cancer (CRC) prognosis has not been thoroughly explored. The present study aimed to develop a novel prognostic model based on PANoptosis-related genes in CRC.
View Article and Find Full Text PDFBuccal mucosal graft (BMG) ureteroplasty, particularly with the anterior-onlay technique, shows promise for treating complex ureteral strictures. However, long and circumferential strictures remain challenging. This study aimed to present the surgical technique of the posterior-inlay and anterior-onlay technique in robotic ureteroplasty with a BMG (RU-BMG).
View Article and Find Full Text PDFArticle Synopsis
- Inflammatory bowel disease (IBD) poses a significant health risk, including an increased chance of developing colorectal cancer (CRC), but understanding and treatment options are still limited.
- This study identifies FBXO22, a protein that helps regulate cellular processes, as a key player in inhibiting inflammation and CRC by promoting the degradation of a specific form of mTOR, which is involved in cancer signaling.
- Treatment with the mTOR inhibitor rapamycin shows promise in reducing colorectal inflammation and cancer effects, highlighting the potential role of FBXO22 and mTOR pathways in colorectal disease management.
Article Synopsis
- Postoperative refractory wounds, which fail to heal within three weeks after surgery, significantly impact patients' quality of life and require effective treatments.* -
- The study analyzed the effects of platelet fibrin plasma (PFP) on wound healing, finding that PFP treatment resulted in over 90% healing within four weeks and improved vascularization and granulation tissue thickness.* -
- PFP was shown to continuously release growth factors that enhance fibroblast and endothelial cell functions, indicating its potential as a viable treatment for promoting wound healing.*
[Etiological analysis of hydronephrosis in adults: A single-center cross-sectional study].
Beijing Da Xue Xue Bao Yi Xue Ban
October 2024
Article Synopsis
- * A total of 767 adult patients were examined, excluding those with ureteral stones or tumors, with data collected over a year at Peking University First Hospital.
- * Findings revealed that non-surgical factors like urinary malformations were the leading cause in over 60% of cases, while iatrogenic injuries from surgeries accounted for about 27% of the cases studied.
Purpose: To develop a novel adaptation of the Whitaker test for assessing the surgical effects of ileal ureter replacement (IUR), and to evaluate its feasibility and effect in the postoperative evaluation.
Patients And Methods: From November 2021 to September 2023, patients undergoing the modified Whitaker test following IUR were prospectively enrolled. The relative pressure was defined as the pelvis pressure minus the bladder pressure.
Article Synopsis
- The study assesses the long-term outcomes of endoscopic management techniques for primary obstructive megaureter (POM) in adults, involving 76 patients treated from September 2015 to January 2024.
- Using endoscopic dilation and additional incision methods, the procedures showed a high success rate of 92.1% over an average follow-up of 42 months, with no intraoperative complications.
- The findings suggest that this endoscopic approach is a safe and effective first-line treatment for adult POM, potentially improving patient outcomes significantly.
Article Synopsis
- * The study details a successful surgery on a 59-year-old woman, utilizing the KangDuo Surgical Robot 2000 Plus, involving harvested ileal segments for ureteral replacement, without any complications.
- * The operation showcased efficient metrics, including a 271-minute operation time and minimal blood loss, but suggests the need for further research with more patients for comprehensively assessing long-term safety and effectiveness.
This work shows how hydrophobicity and porosity can be incorporated into copper catalyst layers (CLs) for the efficient electroreduction of CO (CORR) in a flow cell. Oxide-derived (OD) Cu catalysts are synthesized using K and Cs as templates, termed respectively as OD-Cu-K and OD-Cu-Cs. CLs, assembled from OD-Cu-K and OD-Cu-Cs, exhibit enhanced CORR performance compared to "unmodified" OD-Cu CL.
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- - The study compares the safety and effectiveness of the KangDuo-Surgical Robot-01 (KD-SR-01) and the da Vinci (DV) systems for robot-assisted radical nephroureterectomy (RARNU) through a multicenter trial involving 58 patients from March 2022 to September 2023.
- - Results showed no significant differences in operative metrics and outcomes between the two systems, with both achieving 100% success rates and no serious complications during a four-week follow-up period.
- - The KD-SR-01 system is deemed safe and effective for RARNU, although the authors recommend further research with larger sample sizes and extended follow-up for more comprehensive results.
Article Synopsis
- The study investigates the role of PIWI-interacting RNAs (piRNAs) and their genetic variants in the risk and progression of prostate cancer (PCa) using data from over 85,000 PCa cases and 166,000 controls.
- A specific genetic variant, rs17201241, is linked to increased expression of PROPER, a piRNA associated with higher risk and severity of PCa, which works by affecting mRNA interactions and promoting cancer progression through the p38 MAPK signaling pathway.
- Targeting PROPER has shown potential in suppressing tumor growth in experimental models, suggesting it could be a valuable target for new PCa treatments.
Article Synopsis
- * Our meta-analysis of 22 studies showed that neurofeedback significantly improves depressive symptoms (Hedges' g = -0.600) and neurophysiological outcomes (Hedges' g = -0.726), with moderate effects on neuropsychological function (Hedges' g = -0.418).
- * We found that longer sessions generally lead to better outcomes, while shorter sessions surprisingly improve neurophysiological results, indicating that neurofeedback could be a viable non-drug therapy for depression.
Article Synopsis
- The KangDuo Surgical Robot (KD-SR) was tested against the da Vinci Si Surgical System (DV-SS-Si) for safety and effectiveness in robot-assisted radical prostatectomy (RARP) for prostate cancer patients.
- A study involved 80 patients, showing that both robots achieved a 100% surgical success rate and similar urinary continence outcomes, although the KD-SR had a longer median operation time.
- Overall, the KD-SR demonstrated comparable short-term results, making it a viable alternative to the DV-SS-Si for prostate cancer surgeries, but the study faced limitations like a short follow-up period.
Article Synopsis
- This study analyzes the outcomes of ileal ureter with ileocystoplasty (IUC) in 20 patients, comparing minimally invasive procedures (like laparoscopic and robotic surgeries) to open surgeries over a period from December 2017 to April 2023.
- Results show that while both methods were effective, minimally invasive surgeries resulted in less blood loss and shorter hospital stays than open surgeries.
- The success rate for IUC was 100%, but the study suggests that larger trials with longer follow-up are necessary for more definitive conclusions.
The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer (PCa) as well as to elucidate biological mechanisms underlying the associations. We first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify risk-associated circRNAs by using the MiOncoCirc database. We then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls, and identified rs11973492 T>C as a significant risk-associated variant (odds ratio = 1.
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- Metabolomics, a growing area in systems biology, studies changes in metabolites to identify biomarkers linked to diseases, particularly cancer, which can enhance diagnosis and treatment interventions.
- There is a lack of comprehensive databases connecting metabolites with cancer processes; however, this review compiled findings from over 573,000 samples and identified 17,083 metabolic biomarkers across various cancer types.
- The new Human Cancer Metabolic Markers Database (HCMMD) was created to help researchers easily access and evaluate metabolite information for cancer diagnosis and progression.
Article Synopsis
- Early-onset prostate cancer (EOPC), which affects men aged 55 or younger, presents a significant genetic risk and shows potential for early detection but typically results in poor prognoses.
- A study involving over 167,000 male participants aimed to develop age-specific polygenic risk scores (PRS) for personalized risk assessment and found that EOPC-PRS was strongly linked to EOPC risk compared to late-onset cases.
- The research highlighted that EOPC is more influenced by genetic factors like family history, while late-onset prostate cancer (LOPC) is more associated with environmental and lifestyle factors.
The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Leveraging two cohorts of 3703 patients, we first perform a genome-wide survival association analysis to develop eight candidate PPSs.
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- Continuous cutaneous urinary diversion can be difficult when the appendix is not available, so the Yang-Monti channel serves as a viable alternative for this purpose.
- A 49-year-old man who had previously undergone total urethrectomy and cystostomy experienced severe bladder irritation and was treated with laparoscopic surgery to create a modified Yang-Monti channel.
- Five years post-surgery, the patient successfully managed clean intermittent catheterization with no complications, reporting satisfaction with his quality of life.