Publications by authors named "Siloni Singh Bhadwal"

Endogenous release of HSO during the enzymatic oxidation of sulfur containing amino acids in mitochondria or insufficiency of sulfite oxidase results in the accumulation of sulfite and thiosulfate in biological fluids affecting mitochondrial homeostasis of brain mitochondria associated with serious clinical symptoms related to neurological disorders. The red fluorescent probe MGQ undergoes self-assembly in water and reveals aggregation induced quenching of fluorescence. MGQ reveals 143-fold and 179-fold increases in fluorescence intensity at 645 nm, respectively, in the presence of HSA and BSA and does not significantly differentiate between two albumins.

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Over the past decade, a plethora of research has illuminated the multifaceted roles of hydrogen sulfide (HS) in plant physiology. This gaseous molecule, endowed with signaling properties, plays a pivotal role in mitigating metal-induced oxidative stress and strengthening the plant's ability to withstand harsh environmental conditions. It fulfils several functions in regulating plant development while ameliorating the adverse impacts of environmental stressors.

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The mining industry has historically served as a critical reservoir of essential raw materials driving global economic progress. Nevertheless, the consequential by-product known as mine tailings has consistently produced a substantial footprint of environmental contamination. With annual discharges of mine tailings surpassing 10 billion tons globally, the need for effective remediation strategies is more pressing than ever as traditional physical and chemical remediation techniques are hindered by their high costs and limited efficacy.

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The limitations of prevailing probes for the detection of human serum albumin (HSA) and HSO make it challenging to apprehend the cooperative effect of both HSA and HSO in biological systems. Herein, we present a multi-responsive fluorescent probe , which distinguishes HSA from bovine serum albumin (BSA) through an ∼104-fold fluorescence enhancement at an emission maximum of 595 nm with HSA and only an ∼10-fold increase at an emission maximum of 615 nm with a shoulder at 680 nm with BSA. The absorbance spectrum of also discriminates HSA and BSA with the respective absorption maxima at 543 nm and at 580 nm.

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