Publications by authors named "Silke Nothdurft"
Article Synopsis
- Statins, commonly prescribed to many adults over 40, can influence cancer cell behavior, particularly in solid tumors, making it vital to study their effects on cancer and patients taking them.
- Research shows that statins can trigger a partial epithelial-to-mesenchymal transition (EMT) in cancer cells, leading to both increased ability for cancer cells to spread and a reduced chance of forming new tumors.
- The study offers a detailed understanding of how statin use impacts various stages of cancer development, progression, and metastasis, highlighting both potential risks and benefits.
Lung cancer mortality largely results from metastasis. Despite curative surgery many patients with early-stage non-small cell lung cancer ultimately succumb to metastatic relapse. Current risk reduction strategies based on cytotoxic chemotherapy and radiation have only modest activity.
View Article and Find Full Text PDFMonoclonal antibodies targeting the epidermal growth factor receptor (EGFR), cetuximab and panitumumab, are a mainstay of metastatic colorectal cancer (mCRC) treatment. However, a significant number of patients suffer from primary or acquired resistance. RAS mutations are negative predictors of clinical efficacy of anti-EGFR antibodies in patients with mCRC.
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