Publications by authors named "Silke Kuehn"
Article Synopsis
- The linear ubiquitin assembly complex (LUBAC), made up of HOIP, HOIL-1, and SHARPIN, is crucial for immune responses, with deficiencies leading to severe issues like immunodeficiency and autoinflammation.
- Two individuals with SHARPIN deficiency exhibited autoinflammatory symptoms but did not have the expected skin problems seen in other cases, and their cells showed reduced immune responses.
- Treatment with anti-TNF therapies successfully resolved the autoinflammatory symptoms in one case, highlighting LUBAC's important role in managing immune cell death and maintaining immune balance in humans.
RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis.
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