Multi-objective optimal decision for orderly power utilization based on improved ε-constraint method in active distribution networks.

With the increasing demand for electricity load in China, orderly power utilization are important measures to alleviate electricity shortages during peak periods. This article establishes a multi-objective optimization model for orderly power utilization in active distribution networks is established, with the optimization objectives of minimizing the total operation cost, minimizing the cost for users, and minimizing the load fluctuation of the system. This model contains a large number of integer variables and nonlinear constraints, which is difficult to solve.

Assessing Causal Relationships Between Periodontitis and Non-alcoholic Fatty Liver Disease: A Two-Sample Bidirectional Mendelian Randomisation Study.

Purpose: To investigate the causality between periodontitis and non-alcoholic fatty liver disease (NAFLD) using a two-sample bidirectional Mendelian randomisation (MR) analysis.

Materials And Methods: Genetic variations in periodontitis and NAFLD were acquired from genome-wide association studies (GWAS) using the Gene-Lifestyle Interaction in Dental Endpoints, a large-scale meta-analysis, and FinnGen consortia. Data from the first two databases were used to explore the causal relationship between periodontitis and NAFLD ("discovery stage"), and the data from FinnGen was used to validate our results ("validation stage").

Corrigendum: The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients.

[This corrects the article DOI: 10.3389/fonc.2023.

Chronic Stress Dampens Lactobacillus Johnsonii-Mediated Tumor Suppression to Enhance Colorectal Cancer Progression.

Unlabelled: Colorectal cancer development and outcome are impacted by modifiable risk factors, including psychologic stress. The gut microbiota has also been shown to be linked to psychologic factors. Here, we found a marked deteriorative effect of chronic stress in multiple colorectal cancer models, including chemically induced (AOM/DSS), genetically engineered (APCmin/+), and xenograft tumor mouse models.

The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients.

Background: Despite the increasing use of preoperative ultrasound evaluation for melanoma, there is limited research on the use of this technique for Acral Melanoma (AM).

Methods: This retrospective study analyzed the electronic medical records of patients who underwent preoperative evaluation for cutaneous melanoma maximum thickness using an 18 MHz probe and histopathological examination between December 2017 and March 2021 at the Department of Dermatology in Xiangya Hospital, Central South University.

Results: A total of 105 patients were included in the study.

Beta-adrenergic receptor blocker propranolol triggers anti-tumor immunity and enhances irinotecan therapy in mice colorectal cancer.

Colorectal cancer (CRC) stands as the second leading cause of cancer-related deaths worldwide with limited available medicines. While drug repurposing comes as a promising strategy for cancer treatment, we discovered that propranolol (Prop), a non-selective β1 and β2 adrenergic receptor blocker, significantly inhibited the development of subcutaneous CT26 CRC and AOM/DSS-induced CRC models. The RNA-seq analysis highlighted the activated immune pathways after Prop treatment, with KEGG analysis enriched in T-cell differentiation.

Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study.

Background: Mohs micrographic surgery (MMS) is the preferable surgery for difficult -to-treat basal cell carcinoma (BCC) but is an expensive, labor-intensive, and time-consuming technique. The aim of this study is to compare the efficacy and safety of photodynamic therapy combined with surgery(S-PDT) versus Mohs micrographic surgery (MMS) for the treatment of difficult-to-treat BCC.

Methods: This was a retrospective, comparative study.

TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.

The transient receptor potential canonical (TRPC) channels, encoded in seven non-allelic genes, are important contributors to calcium fluxes, are strongly associated with various diseases. Here we explored the consequences of ablating all seven TRPCs in mice focusing on colitis. We discovered that absence of all seven TRPC proteins in mice (TRPC HeptaKO mice) promotes the development of dextran sulfate sodium (DSS)-induced colitis.

Preoperative Ultrasound-Guided Incisional Biopsy Enhances the Pathological Accuracy of Incisional Biopsy of Cutaneous Melanoma: A Prospective Clinical Trial in Chinese Patients.

Objectives: To assess the feasibility of preoperative ultrasound (US)-guided incisional biopsy through a prospective controlled clinical trial.

Methods: This was a prospective, double-arm, single-center study of Chinese patients. Thirty patients were enrolled in the study.

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury.

The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence analysis of kidneys in AKI and normal mice to explore the pathway mechanism of ferroptosis.

Sustainable Fenton-like degradation of methylene blue over MnO-loaded poly(amidoxime-hydroxamic acid) cellulose microrods.

Catalysts based on cellulose/metal oxide hybrids are considered effective for the remediation of dye wastewater. However, the difficult recovery of commonly used nanocellulose and the weak binding strength of metal oxide nanoparticles restrict their wide application. Herein, MnO nanoparticle-loaded poly(amidoxime-hydroxamic acid) modified microcrystalline cellulose (pAHA-MCC@MnO) catalysts were synthesized via an oximation reaction followed by in-situ growth.

Nitrogen-Doped Carbon Networks with Consecutive Conductive Pathways from a Facile Competitive Carbonization-Etching Strategy for High-Performance Energy Storage.

Recently, new carbonization strategies for synthesizing structure-controlled and high-performance carbon electrode materials have attracted great attentions in the field of energy storage and conversion. Here a competitive carbonization-etching strategy to prepare nitrogen-doped carbon polyhedron@carbon nanosheet (NCP@CNS) hybrids derived from zeolitic imidazolate framework-8 is presented. Consecutive conductive networks are constructed in the NCP@CNS hybrids during a unique carbonization-etching pyrolysis, where a competition between the formation of NCPs and CNSs exists.

Extreme Environmental Thermal Shock Induced Dislocation-Rich Pt Nanoparticles Boosting Hydrogen Evolution Reaction.

Crystal structure engineering of nanomaterials is crucial for the design of electrocatalysts. Inducing dislocations is an efficient approach to generate strain effects in nanomaterials to optimize the crystal and electronic structures and improve the catalytic properties. However, it is almost impossible to produce and retain dislocations in commercial mainstream catalysts, such as single metal platinum (Pt) catalysts.

The Classification of Six Common Skin Diseases Based on Xiangya-Derm: Development of a Chinese Database for Artificial Intelligence.

Background: Skin and subcutaneous disease is the fourth-leading cause of the nonfatal disease burden worldwide and constitutes one of the most common burdens in primary care. However, there is a severe lack of dermatologists, particularly in rural Chinese areas. Furthermore, although artificial intelligence (AI) tools can assist in diagnosing skin disorders from images, the database for the Chinese population is limited.

Short-term PM and cardiovascular admissions in NY State: assessing sensitivity to exposure model choice.

Background: Air pollution health studies have been increasingly using prediction models for exposure assessment even in areas without monitoring stations. To date, most studies have assumed that a single exposure model is correct, but estimated effects may be sensitive to the choice of exposure model.

Methods: We obtained county-level daily cardiovascular (CVD) admissions from the New York (NY) Statewide Planning and Resources Cooperative System (SPARCS) and four sets of fine particulate matter (PM) spatio-temporal predictions (2002-2012).

Prevalence and risk factors of atrioventricular block among 15 million Chinese health examination participants in 2018: a nation-wide cross-sectional study.

Background: Nationwide data on the prevalence of atrioventricular (AV) block are currently unavailable in China. Thus, we aimed to assess the prevalence and risk factors of AV block among Chinese health examination adults.

Methods: A total of 15,181,402 participants aged ≥ 18 years (mean age 41.

Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis.

Background: Graphene oxide (GO), a novel carbon-based nanomaterial, has promising applications in biomedicine. However, it induces potential cytotoxic effects on the gastrointestinal (GI) tract cells, and these effects have been largely uncharacterized. The present study aimed to explore the toxic effects of GO on the intestinal tract especially under pre-existing inflammatory conditions, such as inflammatory bowel disease (IBD), and elucidate underlying mechanisms.

Graphene oxide aggravated dextran sulfate sodium-induced colitis through intestinal epithelial cells autophagy dysfunction.

Graphene oxide (GO) is one of the most promising nanomaterials used in biomedicine. However, studies about its adverse effects on the intestine in state of inflammation remain limited. This study aimed to explore the underlying effects of GO on intestinal epithelial cells (IECs) in vitro and colitis in vivo.

Molten salt-confined pyrolysis towards carbon nanotube-backboned microporous carbon for high-energy-density and durable supercapacitor electrodes.

The development of a green and scalable construction of a three-dimensional (3D) hierarchically porous carbon as an electrode material for supercapacitors is promising but challenging. Herein, a carbon nanotube-backboned microporous carbon (CNT-MPC) was prepared by molten salt-confined pyrolysis, during which the salt eutectics simultaneously acted as a high-temperature reaction solvent and reusable template. Among the CNT-MPC, the CNT backbone provided a 3D conductive framework, whereas the MPC sheath possessed integrated mesopores and micropores as an efficient ion reservoir.

Dislocation-Strained IrNi Alloy Nanoparticles Driven by Thermal Shock for the Hydrogen Evolution Reaction.

Designing high-performance and low-cost electrocatalysts is crucial for the electrochemical production of hydrogen. Dislocation-strained IrNi nanoparticles loaded on a carbon nanotube sponge (DSIrNi@CNTS) driven by unsteady thermal shock in an extreme environment are reported here as a highly efficient hydrogen evolution reaction (HER) catalyst. Experimental results demonstrate that numerous dislocations are kinetically trapped in self-assembled IrNi nanoparticles due to the ultrafast quenching and different atomic radii, which can induce strain effects into the IrNi nanoparticles.

M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/ β-Catenin Signalling Axis.

Background And Aims: M2 phenotype macrophages are involved in the resolution of inflammation and intestinal repair. Exosomes are emerging as important mediators of intercellular communication in the mucosal microenvironment.

Methods: M2 macrophages were transfected with or without miR-590-3p.

Nanomanufacturing of RGO-CNT Hybrid Film for Flexible Aqueous Al-Ion Batteries.

A highly electrically conductive film-type current collector is an essential part of batteries. Apart from the metal-based current collectors, lightweight and highly conductive carbon materials such as reduced graphene oxide (RGO) and carbon nanotubes (CNTs) show great potential as current collectors. However, traditional RGO manufacturing usually requires a long time and high energy, which decreases the product yielding rate and manufacturing efficiency.

Short- and intermediate-term exposure to NO and mortality: A multi-county analysis in China.

Nitrogen dioxide (NO) is a well-established traffic emissions tracer and has been associated with multiple adverse health outcomes. Short- and long-term exposure to NO has been studied and is well-documented in existing literature, but information on intermediate-term NO effects and mortality is lacking, despite biological plausibility. We obtained daily NO and mortality data from 42 counties in China from 2013 to 2015.