Publications by authors named "Silene Silvera-Ruiz"
Article Synopsis
- The study investigates cellular immunity responses against SARS-CoV-2 among patients in Córdoba, Argentina, during two distinct waves of the pandemic that featured different viral variants and social behavior.
- Findings reveal a disruption in lymphocyte populations, specifically noting an increase in B cells and a decrease in CD3 T cells compared to healthy donors, with a more significant reduction in Tregs among severe cases.
- Results suggest a potential new biomarker, the CD8/CD8 index, for predicting disease progression, as it correlated with increased severity while also showing altered effector cytokine production in T cell populations.
The hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a rare autosomal recessive inborn error of the urea cycle caused by mutations in the gene. Besides the well-known metabolic complications, patients often present intercurrent infections associated with acute hyperammonemia and metabolic decompensation. However, it is currently unknown whether intercurrent infections are associated with immunological alterations besides the known metabolic imbalances.
View Article and Find Full Text PDFUrogenital inflammation is a known cause of male infertility. Increased levels of inflammatory cytokines, leukocyte counts and oxidative stress are highly detrimental for sperm quality thus compromising male fertility. Although cytokines affect sperm by recruiting and activating leukocytes consequently inducing tissue inflammation and oxidative stress, scarce to absent data have been reported about the putative direct effects of inflammatory cytokines on spermatozoa.
View Article and Find Full Text PDFIntroduction: Pulmonary hypertension (PH) is a major cause of morbi-mortality among patients with congenital heart disease (CHD) and also a potentially severe complication after surgical repair. Oral citrulline, a precursor to NO synthesis, is safe and efficacious for decreasing the risk of postoperative PH. Objective:
Objetive: The aim of the present study was to investigate in pediatric patients the changes of plasma citrulline, arginine, homocysteine and nitric oxide (NO) metabolites and pulmonary artery pressures (PAP) pre-post cardiac surgery in order to describe our population status with regard to the risk of pulmonary hypertension and look for potential biomarkers for early detection and treatment.
Background: The incidence, prevalence, and molecular epidemiology of urea cycle disorders (UCDs) in Argentina remain underexplored. The present study is the first to thoroughly assess the clinical and molecular profiles of UCD patients examined at a single reference center in Argentina.
Results: Forty-nine UCD cases were collected.