Phase I study of a candidate vaccine based on recombinant HIV-1 gp160 (MN/LAI) administered by the mucosal route to HIV-seronegative volunteers: the ANRS VAC14 study.

One goal of HIV vaccination is to achieve high mucosal levels of specific secretory IgA (SIgA). In order to elicit specific SIgA antibodies against human immunodeficiency virus type-1 (HIV-1), a vaccine must be administered by the mucosal route, to the nasal or vaginal mucosa for example. We report here the results of the first phase I, randomized, open-label trial designed to assess the mucosal tolerability and immunogenicity of a candidate vaccine (recombinant protein HIV-1 gp160MN/LAI with or without DC-Chol adjuvant) administered by the nasal or vaginal route.

White paper of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) on multimodality imaging.

New multimodality imaging systems bring together anatomical and molecular information and require the competency and accreditation of individuals from both radiology and nuclear medicine. This paper sets out the positions and aspirations of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) working together on an equal and constructive basis for the future benefit of both specialties. ESR and EANM recognise the importance of coordinating working practices for multimodality imaging systems and that undertaking the radiology and nuclear medicine components of imaging with hybrid systems requires different skills.

White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging.

Introduction: New multimodality imaging systems bring together anatomical and molecular information and require the competency and accreditation of individuals from both nuclear medicine and radiology.

Aim: This paper sets out the positions and aspirations of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) working together on an equal and constructive basis for the future benefit of both specialties.

Discussion: EANM and ESR recognise the importance of coordinating working practices for multimodality imaging systems and that undertaking the nuclear medicine and radiology components of imaging with hybrid systems requires different skills.

Role of modern imaging technology in the implementation of pediatric cochlear implants.

Since 1989, 40 patients have received cochlear implants in our institution. Over the past 2 years, 17 children among these patients have undergone radiographic assessment combining magnetic resonance imaging (MRI) and high-resolution computed tomography (CT) scanning. Imaging is not essential, and is only used after assessment by a multidisciplinary team.

Legg-Perthes-Calvé disease: staging by MRI using gadolinium.

Twenty-one patients (26 hips) with typical signs of Legg-Perthes-Calvé (LPC) disease on plain radiographs were explored by MRI. Patients were imaged with a 0.5 T MR unit.

[Value of magnetic resonance imaging associated with x-ray computed tomography in the screening of residual cholesteatoma after primary surgery].

Several recent studies have described the magnetic resonance imagery (MRI) of cholesteatomas. For certain authors the MR images are specific after Gadolinium injection. This radio-surgical study included 16 patients who underwent a tympanoplasty with supra and retromeatic masto-attictomy for a cholesteatoma and for whom a second operation was planned.

[Role of modern imaging (tomodensitometry and MRI) in cochlear implantation in children].

Since 1989, 40 patients have received implants in the O.R.L.

[Calcification of the umbilical artery in small infants].

The practice of systematic X ray screening for congenital dislocation of the hip leads to the discovery of a somewhat rare anomaly: the calcification of the vestigial segment of the umbilical artery. The authors describe 6 cases of this peculiar condition of which the diagnosis is easy and does not necessitate any complementary investigation. This finding has no pathological significance; this condition must be considered as a normal variant.

Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases.

We report 2 cases of thoracic neural crest tumors complicating the course in patients with Beckwith-Wiedemann syndrome (BWS). In the first patient, a thoracic neuroblastoma was fortuitously discovered at age 3 months on a chest film prior to a partial glossectomy. In the follow-up left nephroblastoma and a right kidney simple cyst appeared.

[Hypertrophic osteoarthropathy and congenital cyanotic heart defects].

The association of hypertrophic osteoarthropathy and chronic pulmonary disease is well known. The authors report two cases of hypertrophic osteoarthropathy and tetralogy of Fallot in childhood. Early surgical treatment of the tetralogy of Fallot accounts for the present scarceness of this association.