Microliquid/Liquid Interfacial Sensors: Biomimetic Investigation of Transmembrane Mechanisms and Real-Time Determinations of Clemastine, Cyproheptadine, Epinastine, Cetirizine, and Desloratadine.

Antihistamines relieve allergic symptoms by inhibiting the action of histamine. Further understanding of antihistamine transmembrane mechanisms and optimizing the selectivity and real-time monitoring capabilities of drug sensors is necessary. In this study, a micrometer liquid/liquid (L/L) interfacial sensor has served as a biomimetic membrane to investigate the mechanism of interfacial transfer of five antihistamines, i.

A graphitic CN nanocomposite-based fluorescence platform for label-free analysis of trace mercury ions.

In this study, a nanocomposite consisting of graphitic carbon nitride nanosheets loaded with graphitic carbon nitride quantum dots (CNQDs/CNNNs) was synthesized a one-step pyrolysis method. This nanocomposite exhibited excellent thermal stability, photobleaching and salt resistance. Then a new fluorescence sensing platform based on CNQDs/CNNNs was constructed, which showed high sensitivity and selectivity towards trace mercury ions (Hg).

Near-infrared dye IRDye800CW-NHS coupled to Trastuzumab for near-infrared II fluorescence imaging in tumor xenograft models of HER-2-positive breast cancer.

Near-infrared II fluorescent probes targeting tumors for diagnostic purposes have received much attention in recent years. In this study, a fluorescent probe for the NIR-II was constructed by using IRDye800CW-NHS fluorescent dye with Trastuzumab, which was investigated for its ability to target HER-2-positive breast cancer in xenograft mice models. This probe was compared with Trastuzumab-ICG which was synthesized using a similar structure, ICG-NHS.

A new ratiometric fluorescence nanosensor based on NaYF:3%Er@NaYF upconversion nanoparticles for sensitive determination of Rose Bengal in water.

Rose Bengal (RB) is used as a sensitizer in ambient water due to its property of catalyzing the production of singlet oxygen (O). However, this property also brings phototoxicity and carcinogenicity. The NaYF:3%Er@NaYF core-shell upconversion nanoparticles (UCNPs) with higher upconversion efficiency was synthesized to detect RB in ambient water.

reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection.

In this work, gold nanoparticles@TiC MXenes nanocomposites with excellent properties were combined with toehold-mediated DNA strand displacement reaction to construct an electrochemical circulating tumor DNA biosensor. The gold nanoparticles were synthesized on the surface of TiC MXenes as a reducing and stabilizing agent. The good electrical conductivity of the gold nanoparticles@TiC MXenes composite and the nucleic acid amplification strategy of enzyme-free toehold-mediated DNA strand displacement reaction can be used to efficiently and specifically detect the non-small cell cancer biomarker circulating tumor DNA KRAS gene.

Monitoring Bipolar Electrochemistry and Hydrogen Evolution Reaction of a Single Gold Microparticle under Sub-Micropipette Confinement.

Herein, an approach to track the process of autorepeating bipolar reactions and hydrogen evolution reaction (HER) on a micro gold bipolar electrode (BPE) is established. Once blocking the channel of the sub-micropipette tip, the formed gold microparticle is polarized into the wireless BPE, which induces the dissolution of the gold at the anode and the HER at the cathode. The current response shows a periodic behavior with three regions: the bubble generation region (I), the bubble rupture/generation region (II), and the channel opening region (III).

Galvani Potential-Dependent Single Collision/Fusion Impacts at Liquid/Liquid Interface: Faradic or Capacitive?

A new subtype of nano-impacts by emulsion droplets via reorganization of the electric double layer (EDL) at the liquid/liquid interface (LLI) is reported. This subtype shows anodic, bipolar, and cathodic transient currents with a potential of zero charge (PZC) dependence, revealing the non-faradic characteristic of single fusion impacts. In addition, the absolute integrated mean charge is proportional to the Galvani potential at the ITIES, indicating that the EDL at the LLI may obey the discrete Helmholtz model.

Confined Synthesis of Silver Wire at the Nanopipette-Liquid/Liquid Interface.

Herein, silver wire is synthesized electrochemically within a nanopipette using the nanopipette-liquid/liquid interface. The - curve characterizes the growth state of the silver wire. The higher rate of current increase indicates the faster electron transfer and the faster growth of the silver wire; conversely, when the current does not increase significantly with time, i.

Variations in Surface Morphologies, Properties, and Electrochemical Responses to Nitro-Analyte by Controlled Electropolymerization of Thiophene Derivatives.

Herein, we reported the fabrication of conjugated microporous polymer (CMP) films based on three thiophene derivatives using a one-step templateless electropolymerization in dichloromethane without any surfactants. The formation of hydrophilic or hydrophobic films with specific morphology is a comprehensive result of the polymerization sites in each monomer, the polymerization rate, and the gas bubble produced in situ during the polymerization process, which can be easily controlled by the experimental conditions, such as electropolymerization method, electrolyte, and "trace water" existed in the organic solvent. Moreover, the electrochemical reduction of metronidazole as a prototypical nitro-analyte at CMP-modified glassy carbon (GC) electrode shows remarkably increased current response compared to nonmodified GC electrode.

Nanosized Difunctional Photo Responsive Magnetic Imprinting Polymer for Electrochemically Monitored Light-Driven Paracetamol Extraction.

Herein, a novel photoresponsive magnetic electrochemical imprinting sensor for the selective extraction of paracetamol from biological samples was designed. In particular, nanosized photoresponsive molecular imprinted polymers were prepared on the surface of magnetic FeO nanoparticles through living radical polymerization of azobenzene. The introduction of a magnetic-controlled glassy carbon electrode makes the immobilization and removal of nanosized photoresponsive molecular imprinted polymers on the magnetic-controlled glassy carbon electrode surface facilely operational.

Application of Coal in Electrochemical Sensing.

In this work, we first report a new application of coal as a novel modified electrode material in electrochemical sensing, achieving excellent electrochemical performance similar to graphene and making the utilization of coal become more multipurpose and more meaningful. Raw coal was first ball-milled, then centrifugated, and finally annealed, thus obtaining annealed coal that possesses lots of edge-plane-like defective sites, resulting in good electron-transfer efficiency and excellent electrocatalytic activity, which makes it promising when used as signal amplifier material and as a modified matrix in electrochemical sensing. And we also described an investigation into the electrochemical and spectroscopic properties of annealed coal samples and their application for the detection of electroactive redox molecules (rutin).