Publications by authors named "Sijin Sunchen"
Article Synopsis
- Glucose stimulates the release of glucagon-like peptide 1 (GLP-1) from intestinal enteroendocrine cells (EECs), but the exact mechanisms behind this process are not fully understood.
- Researchers conducted experiments using STC-1 cells to study how calcium signaling, involving TRPV4 channels and Na/Ca exchanger 1 (NCX1), regulates glucose-induced GLP-1 release.
- Their findings suggest that the coupling of TRPV4 and NCX1 is crucial for this signaling process, highlighting its potential as a target for new treatments for glycometabolic diseases.
Background: The micronutrient zinc (Zn) is critical for cell function as intracellular signaling and endogenous ligand for Zn sensing receptor (ZnR). Although cytosolic Zn () signaling in the vascular system was studied previously, role of the ZnR has not been explored in vascular physiology.
Methods: ZnR-mediated relaxation response of human submucosal arterioles and the mesenteric arterioles from wide-type (WT), ZnR and TRPV4 mice were determined by a Mulvany-style wire myograph.