Hotspots of nitrogen losses from anthropogenic sources in the Huang-Huai-Hai Basin, China.

Poor management of nitrogen (N) can lead to serious environmental problems, such as air and water pollution. The accurate identification of priority control areas and emission sources is critical for making effective decisions regarding sustainable N management. This study aimed to identify hotspots for N losses and quantitatively analyze the relative contributions of different emission sources in the Huang-Huai-Hai Basin at the county scale.

The impact of emissions controls on atmospheric nitrogen inputs to Chinese river basins highlights the urgency of ammonia abatement.

Excessive nitrogen (N) deposition affects aquatic ecosystems worldwide, but effectiveness of emissions controls and their impact on water pollution remains uncertain. In this modeling study, we assess historical and future N deposition trends in Chinese river basins and their contributions to water pollution via direct and indirect N deposition (the latter referring to transport of N to water from N deposited on land). The control of acid gas emissions (i.

A glycolysis-related signature to improve the current treatment and prognostic evaluation for breast cancer.

Background: As a heterogeneous malignancy, breast cancer (BRCA) shows high incidence and mortality. Discovering novel molecular markers and developing reliable prognostic models may improve the survival of BCRA.

Methods: The RNA-seq data of BRCA patients were collected from the training set The Cancer Genome Atlas (TCGA)-BRCA and validation set GSE20685 in the Gene Expression Omnibus (GEO) databases.

Neuroprotective effects of takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1.

Transforming growth factor β-activated kinase 1 (TAK1) plays a significant role in controlling several signaling pathways involved with regulating inflammation and apoptosis. As such, it represents an important potential target for developing treatments for traumatic brain injury (TBI). Takinib, a small molecule and selective TAK1 inhibitor, has potent anti-inflammatory activity and has shown promising activity in preclinical studies using rat models to evaluate the potential neuroprotective impact on TBI.

Source apportionment of atmospheric ammonia in suburban Beijing revealed through N-stable isotopes.

Addressing the urgent issue of atmospheric ammonia (NH) emissions is crucial in combating poor air quality in megacities. Previous research has highlighted the significant contribution of nonagricultural sources, particularly fossil fuel emissions, to urban NH levels. However, there is limited assessment of NH dynamics in suburban areas.

WITHDRAWN: Rare plexiform neurofibroma of the scrotum - A case report.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.

Identification of prognostic biomarkers for cervical cancer based on programmed cell death-related genes and assessment of their immune profile and response to drug therapy.

Background: Programmed cell death (PCD) has been widely investigated in various human diseases. The present study aimed to identify a novel PCD-related genetic signature in cervical squamous cell carcinoma (CESC) to provide clues for survival, immunotherapy and drug sensitization prediction.

Methods: Single-sample gene set enrichment analysis (ssGSEA) was used to quantify the PCD score and assess the distribution of PCD in clinicopathological characteristics in The Cancer Genome Atlas (TCGA)-CESC samples.

CEP20 promotes invasion and metastasis of non-small cell lung cancer cells by depolymerizing microtubules.

Worldwide, Lung cancer is the leading cause of cancer-related death and poses a direct health threat, non-small cell lung cancer (NSCLC) is the most common type. In this study, we demonstrated that centrosomal protein 20 (CEP20) is upregulated in NSCLC tissues and associated with cancer invasion metastasis. Notably, CEP20 depletion inhibited NSCLC cell proliferation, migration, and microtubule polymerization.

Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice.

Multiple sclerosis (MS) is a chronic disease that is characterized by demyelination and neuronal damage. Experimental autoimmune encephalomyelitis (EAE) mice are used to model the disease progression of MS and mirror MS-like pathology. Previous researches have confirmed that inhibition of NLRP3 inflammasome significantly alleviated the severity of EAE mice and the demyelination of spinal cord, but its effect on neuronal damage and oligodendrocyte loss in the brain remains unclear.

Ammonia mitigation campaign with smallholder farmers improves air quality while ensuring high cereal production.

Reducing cropland ammonia (NH) emissions while improving air quality and food supply is a challenge, particularly in China where there are millions of smallholder farmers. We tested the effectiveness of a tailored nitrogen (N) management strategy applied to wheat-maize cropping systems in 'demonstration squares' across Quzhou County in the North China Plain. The N-management techniques included optimal N rates, deep fertilizer placement and application of urease inhibitors, implemented through cooperation between government, researchers, businesses and smallholders.

Serum cytokine analysis in a cohort of advanced non-small cell lung cancer treated with PD-1 inhibitors reveals predictive markers of CXCL12.

Background: The circulating predictive factors for the outcomes of advanced non-small cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs) remain elusive. We aimed to assess the predictive value of circulating cytokines for outcomes.

Methods: Serum samples of 102 advanced-stage NSCLC patients who underwent immunotherapy were collected at baseline.

MiR-95-3p acts as a prognostic marker and promotes cervical cancer progression by targeting VCAM1.

Background: Cervical cancer patients have a high risk of metastasis and a poor prognosis with shorter disease-free survival. Thus, novel biomarkers and feasible therapies urgently need to be discovered. Previous studies have shown that miR-95-3p plays crucial roles in several cancer types.

Polycyclic and nitro-polycyclic aromatic hydrocarbon pollution characteristics and carcinogenic risk assessment of indoor kitchen air during cooking periods in rural households in North China.

Medium-flow atmospheric samplers were used to collect particulate (PM) and gaseous samples from the indoor kitchen of each of 35 randomly selected rural houses in North China while a meal was being cooked. The concentrations of 16 polycyclic aromatic hydrocarbons (PAHs) and 9 nitro-PAHs (NPAHs) in the samples were quantified by high-performance liquid chromatography (HPLC). This study provided the real PAH and NPAH pollution characteristics and carcinogenic risk produced by cooking in rural indoor kitchens in North China.

The proximity of ideas: An analysis of patent text using machine learning.

This paper introduces a measure of the proximity in ideas using unsupervised machine learning. Knowledge transfers are considered a key driving force of innovation and regional economic growth. I explore knowledge relationships by deriving vector space representations of a patent's abstract text using Document Vectors (Doc2Vec), and using cosine similarity to measure their proximity in ideas space.

Amino acid-amidated pectin: Preparation and characterization.

There is interest in extending the functionality of natural polymers using simple chemical derivatization methods. In this study, the ability of pectin to react with various amino acids (40 °C) in aqueous solution without a catalyst was investigated, including glutamic acid, glycine, cysteine, lysine, and arginine. Only glycine, lysine, and arginine could form conjugates with pectin under these conditions.

Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration.

Microtubules are highly dynamic filaments assembled from αβ-tubulin heterodimers and play important roles in many cellular processes, including cell division and migration. Microtubule dynamics is tightly regulated by microtubule-associated proteins (MAPs) that function by binding to microtubules or free tubulin dimers. Here, we report that FOR20 (FOP-related protein of 20 kDa), a conserved protein critical for ciliogenesis and cell cycle progression, is a previously uncharacterized MAP that facilitates microtubule depolymerization and promotes cell migration.

[Impact of Ammonia and HO on Bromate and Disinfection By-products Control].

A pilot-scale study with conventional water treatment and ozone-biological activated carbon (O-BAC) treatment was conducted to evaluate the impact of ammonia and hydrogen peroxide (HO) addition on the bromate and disinfection by-products formation potential (DBPFP) control, with bromide containing water as raw water. It was found that bromate concentration would exceed 10.00 μg·L as ozone doses were higher than 1.

Characteristics of polycyclic aromatic hydrocarbons in food oils in Beijing catering services.

The concentrations and characteristics of 16 polycyclic aromatic hydrocarbons (PAHs) in 48 oil samples randomly collected from 30 catering services that employ six cooking methods were quantified via high-performance liquid chromatography (HPLC). These 16 PAHs were detected in almost all of the samples. The levels of Σ16PAHs, Σ4PAHs, benzo[a]pyrene (BaP), and total BaP equivalents (ΣBaP) for the six cooking methods exceeded the legal limit.