In this paper, MoS-CuGaO composites were successfully synthesized by hydrothermal method. The composites were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), respectively. The specific surface area and pore size distribution were obtained by N adsorption-desorption isotherms.
View Article and Find Full Text PDFBackground: In the present study, we explored the role of N-methyladenosine (mA) modification of long non-coding RNAs (lncRNAs) and its association with ferroptosis in lens epithelium cells (LECs) of age-related cataract (ARC).
Methods: Through mA RNA immunoprecipitation sequencing (mA-RIP-seq) and RNA sequencing (RNA-seq), we identified mA mediated and differentially expressed lncRNAs (dme-lncRNAs) in ARC patients. Based on bioinformatics analysis, we selected critical dme-lncRNAs and pathways associated with ARC formation to reveal their potential molecular mechanisms.
Purpose: Age-related cataract (ARC) is associated with the deregulation of transcription and defects in DNA repair in lens epithelial cells (LECs). DCLRE1A acted in DNA interstrand cross-links pathway to improve DNA replication and transcription. The aim of this study was to examined the further regulatory effect on DCLRE1A in the lncRNA-miRNA-mRNA network using a cell model of DCLRE1A overexpression (OE-DCLRE1A) in LECs.
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