Publications by authors named "Sijie Bao"

In this paper, MoS-CuGaO composites were successfully synthesized by hydrothermal method. The composites were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), respectively. The specific surface area and pore size distribution were obtained by N adsorption-desorption isotherms.

View Article and Find Full Text PDF

Background: In the present study, we explored the role of N-methyladenosine (mA) modification of long non-coding RNAs (lncRNAs) and its association with ferroptosis in lens epithelium cells (LECs) of age-related cataract (ARC).

Methods: Through mA RNA immunoprecipitation sequencing (mA-RIP-seq) and RNA sequencing (RNA-seq), we identified mA mediated and differentially expressed lncRNAs (dme-lncRNAs) in ARC patients. Based on bioinformatics analysis, we selected critical dme-lncRNAs and pathways associated with ARC formation to reveal their potential molecular mechanisms.

View Article and Find Full Text PDF
Article Synopsis
  • High myopia is a significant risk factor for developing nuclear cataracts, primarily due to oxidative damage affecting mitochondrial balance in lens epithelial cells (LECs).
  • This study examined the alterations in mitochondrial homeostasis in LECs from patients with high-myopia cataracts (HMC) versus those with age-related cataracts (ARC), utilizing various assays to analyze mitochondrial behavior and gene expression.
  • Results indicated decreased mitochondrial DNA in HMC patients and increased oxidative stress, along with notable changes in mitochondrial markers suggesting disrupted homeostasis and increased mitophagy, particularly indicated by morphological changes observed through transmission electron microscopy.
View Article and Find Full Text PDF

Purpose: Age-related cataract (ARC) is associated with the deregulation of transcription and defects in DNA repair in lens epithelial cells (LECs). DCLRE1A acted in DNA interstrand cross-links pathway to improve DNA replication and transcription. The aim of this study was to examined the further regulatory effect on DCLRE1A in the lncRNA-miRNA-mRNA network using a cell model of DCLRE1A overexpression (OE-DCLRE1A) in LECs.

View Article and Find Full Text PDF