Potassium channels and epilepsy.

With the development and application of next-generation sequencing technology, the aetiological diagnosis of genetic epilepsy is rapidly becoming easier and less expensive. Additionally, there is a growing body of research into precision therapy based on genetic diagnosis. The numerous genes in the potassium ion channel family constitute the largest family of ion channels: this family is divided into different subtypes.

Polarization Guided Specular Reflection Separation.

Since specular reflection often exists in the real captured images and causes deviation between the recorded color and intrinsic color, specular reflection separation can bring advantages to multiple applications that require consistent object surface appearance. However, due to the color of an object is significantly influenced by the color of the illumination, the existing researches still suffer from the near-duplicate challenge, that is, the separation becomes unstable when the illumination color is close to the surface color. In this paper, we derive a polarization guided model to incorporate the polarization information into a designed iteration optimization separation strategy to separate the specular reflection.

Long-Term Outcome of Secondary Steroid-Resistant Nephrotic Syndrome in Chinese Children.

Introduction: Secondary steroid-resistant nephrotic syndrome (SRNS) refers to the condition when patients with initial steroid-sensitive nephrotic syndrome develop steroid resistance in subsequent relapses. Long-term outcomes of secondary SRNS in children are uncertain.

Methods: This was a single-center retrospective study of 56 children with secondary SRNS between 2006 and 2016.

Effects of alternative remission criteria on outcome of pediatric proliferative lupus nephritis: a multi-center retrospective study of pediatric proliferative lupus nephritis.

Objectives: To observe the induction efficacy of mycophenolate mofetil and cyclophosphamide under different complete remission (CR) criteria in children with proliferative lupus nephritis, and to further explore the factors influencing the judgment of remission.

Methods: From 2003 to 2019, children who diagnosed proliferative lupus nephritis underwent induction therapy of MMF or CYC in three hospitals were consecutively collected. Based on this population, we compared CR rates between two groups under six CR criteria selected from related recommendations and clinical trials.

A Sparse Representation Based Joint Demosaicing Method for Single-Chip Polarized Color Sensor.

The emergence of the single-chip polarized color sensor now allows for simultaneously capturing chromatic and polarimetric information of the scene on a monochromatic image plane. However, unlike the usual camera with an embedded demosaicing method, the latest polarized color camera is not delivered with an in-built demosaicing tool. For demosaicing, the users have to down-sample the captured images or to use traditional interpolation techniques.

[Clinicopathological features of children with lupus nephritis with positive antineutrophil cytoplasmic antibody].

Objective: To study the clinicopathological features of children with lupus nephritis (LN) with positive anti-neutrophil cytoplasmic antibody (ANCA).

Methods: A retrospective analysis was performed for the children who were diagnosed with LN in the First Affiliated Hospital of Sun Yat-sen University from January 2003 to December 2019. According to the results of serum ANCA, they were divided into two groups: ANCA-positive group (=59) and ANCAnegative group (=454).

Case Report: Denys-Drash Syndrome With Causative Variant Presenting as Atypical Hemolytic Uremic Syndrome.

The variant is confirmed to be pathogenic for Denys-Drash syndrome (DDS), a rare disorder characterized by early-onset nephrotic syndrome and renal failure, pseudo-hermaphroditism, and a high risk of Wilms' tumor. Several cases of DDS presenting with atypical hemolytic uremic syndrome (aHUS) have been reported. Here we report the case of a 2-year-old child who was diagnosed with missense variant, associated with DDS and initial presentation of aHUS.

Convolutional demosaicing network for joint chromatic and polarimetric imagery.

Due to the latest progress in image sensor manufacturing technology, the emergence of a sensor equipped with an RGGB Bayer filter and a directional polarizing filter has brought significant advantages to computer vision tasks where RGB and polarization information is required. In this regard, joint chromatic and polarimetric image demosaicing is indispensable. However, as a new type of array pattern, there is no dedicated method for this challenging task.

Investigation of the kinetic process of solid phase microextraction in complex sample.

The presence of complex matrix in the aquatic system affects the environmental behavior of hydrophobic organic compounds (HOCs). In the current study, an automated solid-phase microextraction (SPME) desorption method was employed to study the effect of 2-hydroxypropyl-β-cyclodextrin (β-HPCD) on the kinetic process of 5 selected polyaromatic hydrocarbons (PAHs) desorbing from the fiber in aqueous sample. The results showed that the added β-HPCD facilitated the desorption rates of PAHs from SPME fiber coating, and the enhancement effect can be predicted by a proposed theoretical model.

Development of a full automation solid phase microextraction method for investigating the partition coefficient of organic pollutant in complex sample.

A fully automated solid phase microextraction (SPME) depletion method was developed to study the partition coefficient of organic compound between complex matrix and water sample. The SPME depletion process was conducted by pre-loading the fiber with a specific amount of organic compounds from a proposed standard gas generation vial, and then desorbing the fiber into the targeted samples. Based on the proposed method, the partition coefficients (Kmatrix) of 4 polyaromatic hydrocarbons (PAHs) between humic acid (HA)/hydroxypropyl-β-cyclodextrin (β-HPCD) and aqueous sample were determined.