Supine bicycle stress echocardiography at low altitude for identification of susceptibility to acute mountain sickness.

Background: Exposure to high altitude may unpredictably lead to acute mountain sickness (AMS). The purpose of this study was to identify the predictors of AMS at low altitude by exercise stress echocardiography (ESE).

Methods: A total of 40 healthy adults were enrolled and underwent comprehensive supine bicycle ESE at low altitude, including pulmonary vascular resistance (PVR), right ventricular (RV) area index at the end of diastole (RVEDAi), B-lines, and inferior vena cava (IVC) diameter.

Role of CALCR expression in liver cancer: Implications for the immunotherapy response.

Liver hepatocellular carcinoma (LIHC) is a prevalent and lethal malignancy with a complex molecular landscape. Fibrosis and ferroptosis are implicated in LIHC progression, yet their roles remain to be elucidated. The present study investigated the expression and prognostic significance of calcitonin receptor (CALCR), a gene that intersects the pathways of fibrosis and ferroptosis, across LIHC and other types of cancer.

Progress in gasless endoscopic thyroidectomy.

Gasless endoscopic thyroidectomy obviates the necessity for carbon dioxide insufflation to establish a surgical workspace, thus mitigating the potential complications associated with this practice. This technique presents several benefits, such as the maintenance of neck functionality, minimal scarring, and enhanced visibility of the surgical field, which contribute to its extensive adoption in clinical settings. The objective of this study is to synthesize the current methodologies of gasless endoscopic thyroidectomy and to evaluate the advantages and disadvantages inherent to each technique.

The effects of fluorinated metal-organic frameworks as additives in polymer-based electrolytes for all-solid-state lithium batteries.

In this study, solid composite electrolytes (SCEs) comprising UIO-66-F(Zr) were obtained by using a simple solution casting method. By introducing fluorinated groups, the interaction between the MOF and the polymer was significantly improved, which not only stabilizes the SEI layer but also improves the ionic conductivity of the SCEs, thus advancing the practical application of solid composite electrolytes in lithium metal batteries.

Facial aging, cognitive impairment, and dementia risk.

Background: Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age and future risk of dementia was not systematically examined.

Objectives: To investigate the relationship between facial age (both subjective/perceived and objective) and cognitive impairment and/or dementia risk.

Soluble hyaluronic acid microneedle arrays mediated RGD-modified liposome delivery for pain relief during photodynamic therapy by blocking TRPV1.

In photodynamic therapy (PDT), reactive oxygen species (ROS) are key products that induce cell death, and increasing amount of ROS is a crucial way to enhance PDT efficacy. However, the generated ROS stimulates the transient receptor potential vanilloid 1 channel (TRPV1), which can be activated in the pain pathway and then exacerbate pain. Herein, we utilized arginine-glycine-aspartate (RGD) peptide-modified liposomes for encapsulation Chlorin e6 (Ce6) and capsazepine (Cz), a receptor antagonist of TRPV1, to prepare drug-loaded liposomes, RLCC.

Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers.

Background: Alterations in DNA methylation (DNAm) have been observed in patients with fatty liver, but whether they are cause or consequence remains unknown. The study aimed to investigate longitudinal association of epigenome-wide DNAm with liver fat content (LFC) in Chinese participants, and explore their temporal relationships.

Methods: Data were obtained from 2 waves over a four-year time period of the Shanghai Changfeng Study (discovery, n = 407 and replication, n = 126).

The association between weight loss behaviors and body weight perception in Chinese adolescents: 2007-2022.

Background: Weight misperceptions are common in children and adolescents, which is related to the engagement of weight loss behaviors. The aim of this study was to investigate the association between body weight perception and weight loss behaviors of lower-calorie diets and increased levels of physical activity (PA).

Methods: The Ningbo Youth Risk Behavior Survey was conducted from 2007 to 2022.

Aggression to Biomembranes by Hydrophobic Tail Chains under the Stimulus of Reductant.

Stimulus-responsive materials hold significant promise for antitumor applications due to their variable structures and physical properties. In this paper, a series of peptides with a responsive viologen derivative, Pep-CV ( = 1, 2, 3) were designed and synthesized. The process and mechanism of the interaction were studied and discussed.

A drug delivery system of siRNA nanoparticles loaded by mesenchymal stem cells on choroidal neovascularization.

To assess mesenchymal stem cells (MSCs) as carriers for  siRNA-loaded nanoparticles (NPs) for targeted therapy of experimental choroidal neovascularization (CNV). A poly (lactic-co-glycolic acid) (PLGA)-core/lipid-shell hybrid NP was designed. The transfection efficacy of MSCs with the hybrid NPs was assessed.

Investigating the shared genetic architecture between depression and subcortical volumes.

Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression and subcortical volumes remain inadequately understood.

Multiscale Tunable Nanorings Based on Bi-Component Micellar-Configuration-Transformation Induced by Hydrophobicity.

Ringy nanostructures are amazing materials, displaying unique optical, magnetic, and electronic properties highly related to their dimensions. A strategy capable of continuously tailoring the diameter of nanorings is the key to elucidating their structure-function relationship. Herein, a method of bi-component micellar-configuration-transformation induced by hydrophobicity for the synthesis of nanorings with diameters ranging from submicron (≈143 nm) to micron (≈4.

Unraveling multi-scale neuroimaging biomarkers and molecular foundations for schizophrenia: A combined multivariate pattern analysis and transcriptome-neuroimaging association study.

Aims: Schizophrenia is characterized by alterations in resting-state spontaneous brain activity; however, it remains uncertain whether variations at diverse spatial scales are capable of effectively distinguishing patients from healthy controls. Additionally, the genetic underpinnings of these alterations remain poorly elucidated. We aimed to address these questions in this study to gain better understanding of brain alterations and their underlying genetic factors in schizophrenia.