Publications by authors named "Sijia Huo"
The type 2 small conductance Ca-activated K channels (SK2) have been considered as one of the most promising therapeutic targets for spinocerebellar ataxias type 2 (SCA2) by playing a critical role in the control of normal purkinje cells (PCs) pacemaking. Herein, a novel series of pyrrolopyrimidine derivatives were designed and synthesized from the lead compound NS13001 as subtype-selective modulators of SK channels. Among them, the halogen-substituted compound 12b (EC = 0.
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- This study examines the genetic factors contributing to the risk of different cancers by analyzing data from 12 genome-wide association studies, involving nearly 910,000 participants.
- Researchers discovered 15 new cancer susceptibility loci and found that some genetic variants are shared between multiple cancer types, despite much of the heritability being specific to individual cancers.
- The findings indicate the importance of using larger sample sizes for more effective cross-cancer analyses, which could unveil additional genetic regions linked to increased cancer risk.