Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy.

Background: Previously, albendazole (ABZ) has been reported as an anti-parasitic drug rather than anti-tumor drug. Our study aim to investigate whether ABZ also has a potential anti-tumor effect by shaping the tumor immune microenvironment and interrogate whether ABZ could synergize with the PD-L1 blockade.

Methods: C57BL/6 mice (C57) were intravenously injected with B16F10-luciferase (B16-luc) cells to establish a lung metastatic melanoma model and subcutaneously inoculated with B16-luc cells to establish a subcutaneous tumor model.

Autofluorescence spectral analysis for detecting urinary stone composition in emulated intraoperative ambient.

The prevalence and disease burden of urolithiasis has increased substantially worldwide in the last decade, and intraluminal holmium laser lithotripsy has become the primary treatment method. However, inappropriate laser energy settings increase the risk of perioperative complications, largely due to the lack of intraoperative information on the stone composition, which determines the stone melting point. To address this issue, we developed a fiber-based fluorescence spectrometry method that detects and classifies the autofluorescence spectral fingerprints of urinary stones into three categories: calcium oxalate, uric acid, and struvite.

Reduced Ca spark activity contributes to detrusor overactivity of rats with partial bladder outlet obstruction.

We tested whether or not altered Ca spark activity accounted for detrusor overactivity (DO) of Wistar rats after partial bladder outlet obstruction (PBOO). We constructed a DO model through PBOO and studied the Ca spark activity of detrusor. By way of using confocal microscopy and the patch-clamp technique, Ca sparks and spontaneous transient outward currents (STOCs) in detrusor myocytes were measured respectively.

Comparative study of wire-integrated urethral catheter versus wire-assisted urethral catheter in difficult male urethral catheterization: a single-center experience.

Background: This study reports the clinical experience of the wire-integrated urethral catheter (WIUC) versus wire-assisted urethral catheter (WAUC) in difficult male urethral catheterization.

Methods: The clinical data of 116 male patients undergoing urinary catheterization with WIUC or WAUC after a failed attempt catheterization in Southwest Hospital from June 2018 to June 2019 were retrospectively analyzed. The time spent during urinary catheterization, cost of consumables, experience rating of catheterization methods and materials assessed by medical staff were compared between WIUC group (n=58) and WAUC group (n=58).

Procalcitonin as an early diagnostic and monitoring tool in urosepsis following percutaneous nephrolithotomy.

To evaluate the value of procalcitonin (PCT) as an early marker for diagnosis and differentiation of without urosepsis, urosepsis, severe urosepsis, and uroseptic shock following PCNL and the ability of PCT to assess the effectiveness of antibiotic therapy in patients with urosepsis. From June 2012 to August 2013, 267 patients undergoing PCNL for renal calculi, and who fulfilled selection criteria, were recruited into our study. The patients' medical records were reviewed retrospectively.

Selective transurethral resection of the prostate combined with transurethral incision of the bladder neck for bladder outlet obstruction in patients with small volume benign prostate hyperplasia (BPH): a prospective randomized study.

Purpose: Transurethral resection of the prostate (TURP) has a high failure rate in patients with small volume benign prostate hyperplasia (BPH) with bladder outlet obstruction (BOO). We describe and report the results of an alternative surgical method, selective transurethral resection of the prostate (STURP) in combination with transurethral incision of the bladder neck (TUIBN).

Methods: Patients were randomized to receive TURP or STRUP+TUIBN in combination with TUIBN.