Publications by authors named "Sihua Lai"
Bioinformatics analysis was performed to reveal the underlying pathogenesis of type 2 diabetes (T2DM) dry eye(DE) and to predict the core targets and potential pathways for electroacupuncture (EA) treatment of T2DM DE, in which key targets such as Toll-likereceptor4 (TLR4), NF-κB and Tumor necrosis factor-α (TNF-α) may be involved. Next, streptozotocin and a high-fat diet were used to generate T2DM-DE rats. Randomly picked EA, fluorometholone, model, and sham EA groups were created from successfully modelled T2DM DE rats.
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- - **Psychotropic medications are widely prescribed but can harm the environment, leading to a need for effective detection methods.**
- The study created a reliable method using ultra-performance liquid chromatography to analyze 47 psychotropic drugs across various water and sludge samples.
- The findings showed that many of these medications persist in wastewater treatment plants, highlighting issues with their removal and potential environmental impact.
Purpose: This study aimed to examine electroacupuncture's influence on ocular pain and its potential modulation of the TNF-ɑ mediated ERK1/2/P2XR signaling pathway in dry eye-induced rat models.
Methods: Male Sprague-Dawley rats with induced dry eye, achieved through extraorbital lacrimal gland removal, were treated with electroacupuncture. Comprehensive metrics such as the corneal mechanical perception threshold, palpebral fissure height, eyeblink frequency, eye wiping duration, behavioral changes in the open field test, and the forced swimming test were employed.