TIVS versus Non-TIVS management of limb vascular injury in limb salvage: systematic review and meta-analysis.

Background: To compare the postoperative complications between temporary intravascular shunts (TIVS) and non-TIVS management in limb salvage surgery for severe limb trauma, and to provide reference for clinical decision making.

Methods: The literature on postoperative complications of limb salvage with and without TIVS was searched in PubMed, Cochrane Library, Embase and MEDLINE from January 2000 to December 2023. References were screened and extracted according to inclusion and exclusion criteria, and meta-analysis was performed using RevMan5.

Diatomaceous organic matter is overlooked but forms disinfection byproducts of high cytotoxicity during chlorination.

Diatomaceous organic matter (DAOM) has the potential to be the main precursor of disinfection byproducts (DBPs) in multiple drinking water sources during diatom blooms. However, characterization of DAOM and subsequent formation of chlorination DBPs, especially at the molecular level, have rarely been studied, let alone the links between DAOM chemodiversity and DBPs' cytotoxicity. Herein three types of DAOM derived from Cyclotella meneghiniana, Synedra ulna, and Fragilaria nanana - which are common species during diatom blooms in drinking water sources - were selected.

Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications.

Multiple myeloma (MM) is a complex and heterogeneous hematologic malignancy characterized by clonal evolution, genetic instability, and interactions with a supportive tumor microenvironment. These factors contribute to treatment resistance, disease progression, and significant variability in clinical outcomes among patients. This review explores the mechanisms underlying MM progression, including the genetic and epigenetic changes that drive clonal evolution, the role of the bone marrow microenvironment in supporting tumor growth and immune evasion, and the impact of genomic instability.

Highly Dispersed Single Clusters Supported Porphyrinic Metal-Organic Frameworks for Synergetic CO Electroreduction to CH.

The electrocatalytic CO reduction is a promising path toward the carbon-neutral goal but remains a huge challenge due to the high activation barrier for CO and poor selectivity. Herein, the highly dispersed triruthenium single cluster (Ru-SCs) is confined into the nanospace of pyrrole-3-carboxylic acid (PyrA)-modified nickel-porphyrin-based metal-organic framework (Ni-PCN-222-PyrA) to form the composite (Ru-SCs@Ni-PCN-222-PyrA) through the pre-coordination confinement strategy. The prepared Ru-SCs@Ni-PCN-222-PyrA can accelerate the selective reduction of CO to CH via electrocatalysis.

Effects of phosphatidylethanolamine on intramuscular fat deposition and key gene identification by transcriptome sequencing in broiler chickens.

High-intensity breeding of broilers has increased meat yield while reducing meat quality. Properly enhancing intramuscular fat (IMF) content is an effective strategy to improve chicken meat quality and boost consumer preference. Given that the role of phosphatidylethanolamine (PE) in chicken IMF metabolism remains unclear, we investigated the effects of PE on the meat quality, as well as the differentiation and gene expression regulation of chicken intramuscular adipocytes (IMAs).

Advances in the Pathogenesis and Treatment Strategies for Type 1 Diabetes Mellitus.

Type 1 diabetes (T1D) is a complex autoimmune disorder distinguished by the infiltration of immune cells into pancreatic islets, primarily resulting in damage to pancreatic β-cells. Despite extensive research, the precise pathogenesis of T1D remains elusive, with its etiology linked to a complex interplay of genetic, immune, and environmental factors. While genetic predispositions, such as HLA and other susceptibility genes, are necessary, they do not fully account for disease development.

Academic Pressure and Psychological Imbalance in High School Students: Predictors of Depression via Polynomial Regression and Response Surface Analysis.

Objective: The purpose of this study was to explore how the congruence between academic pressure and psychological imbalance affects depressive symptoms in adolescents and to further explore grade-level differences in these effects among high school students.

Methods: The study population consisted of 29,975 high school students from 20 schools in Liuyang City, Hunan Province. The Mental Health Scale for Secondary School Students (MSSMHS) and Self-Depression Scale (SDS) were used to assess academic pressure, psychological imbalance and depressive symptoms.

OATP1A2 mediates Aβ transport and may be a novel target for the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disease with an unknown cause. Many studies have suggested that the imbalance between the clearance and accumulation of β-amyloid protein (Aβ) in the brain of AD patients is the main cause of AD development of AD. Meanwhile, drug transporters play a key role in the transport of drugs and endogenous substances as well as in the development of many diseases.

Childhood Maltreatment and Adolescent Eating Disorders' Symptoms: A Moderated Mediation Model of Social Anxiety and Physical Activity.

Background: Childhood maltreatment contributes to an increased risk of eating disorders in adolescents. However, less is known regarding the underlying mechanism between childhood maltreatment and eating disorders' symptoms. This study tested the mediation effect of social anxiety in the association between childhood maltreatment and eating disorders' symptoms and whether this mediation was moderated by physical activity.

Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice.

Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis.

Curcumin protects porcine granulosa cells and mouse ovary against reproductive toxicity of aflatoxin B1 via PI3K/AKT signaling pathway.

Aflatoxin B1 (AFB1) is a widespread food contaminant with toxic effects on female reproductive system. This concerns the human public health and the development of the livestock industry. Effective and feasible measures against reproductive toxicity of AFB1 are also unknown.

Deep learning based approach: automated gingival inflammation grading model using gingival removal strategy.

Gingival inflammation grade serves as a well-established index in periodontitis. The aim of this study was to develop a deep learning network utilizing a novel feature extraction method for the automatic assessment of gingival inflammation. T-distributed Stochastic Neighbor Embedding (t-SNE) was utilized for dimensionality reduction.

Psychiatric assessment and therapy in an adolescent with ALG6-CDG: a six-month follow-up case report.

ALG6-congenital disorder of glycosylation (ALG6-CDG) is a complex of rare inherited disorders caused by mutations in the ALG6 gene, which encodes the α-1,3-glucosyltransferase enzyme required for N-glycosylation. ALG6-CDG affects multiple systems and exhibits clinical heterogeneity. Besides developmental delays and neurological signs and symptoms, behavioral and psychological symptoms are also an important group of clinical features of ALG6-CDG.

The Global Research Trends on Intrinsic Capacity of Older Adults: A Bibliometric and Visual Analysis of Papers Published During 2015-2023.

Objective: The concept of intrinsic capacity (IC) revolves around healthy aging and active aging. Since the Introduction of the concept by the World Health Organization in 2015, a series of studies have been conducted by scholars from multiple fields. However, no bibliometric analysis has systematically investigated this issue.

Core items selection and psychometric properties of the adult attention-deficit hyperactivity disorder self-report scale-chinese short version (ASRS-CSV).

Objective: This study aimed to develop and validate the Chinese Short Version of the Adult ADHD Self-Report Scale (ASRS-CSV), addressing the need for culturally appropriate diagnostic tools for Attention-Deficit Hyperactivity Disorder (ADHD) in the Chinese adult population.

Methods: Utilizing a combination of intergroup difference analysis, factor analysis, and network analysis, we identified core ADHD symptoms pertinent to the Chinese cultural context. The study involved two samples: a vocational and technical school sample (N=1144) and an internet sample (N=1654), comprising adults aged 16-25 years.

Curcumin alleviates Aflatoxin B1-triggered chicken liver necroptosis by targeting the LOC769044/miR-1679/STAT1 axis.

Aflatoxin B1 (AFB1) is an unavoidable environmental toxin. The accumulation of AFB1 and its metabolites in the liver poses a threat to both human and animal health. Curcumin exhibits anti-oxidative, anti-tumor, and anti-inflammatory properties.

Renal Tissue-Derived Exosomal miRNA-34a in Diabetic Nephropathy Induces Renal Tubular Cell Fibrosis by Promoting the Polarization of M1 Macrophages.

Background: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease, and the activation and infiltration of phagocytes are critical steps of DN. This study aimed to explore the mechanism of exosomes in macrophages and diabetes nephropathy and the role of miRNA-34a, which might provide a new path for treating DN.

Materials And Methods: The DN model was established, and the success of the model establishment was confirmed by detecting general indicators, HE staining, and immunohistochemistry.

Unrevealing the therapeutic potential of artesunate against emerging zoonotic infection in the murine model.

Babesiosis, a zoonotic blood protozoal disease, threatens humans and animals and is difficult to treat due to growing antimicrobial resistance. The study aimed to investigate the therapeutic efficacy of artesunate (AS), a well-known derivative of artemisinin, against () using a murine infection model. Male BALB/c mice (6 weeks old; 15 per group) were chosen and randomly divided into 1) the control group, 2) group, and 3) the  + artesunate treatment groups.

A novel induced pluripotent stem cell model of Schwann cell differentiation reveals - related gene regulatory networks of the extracellular matrix.

Schwann cells are vital to development and maintenance of the peripheral nervous system and their dysfunction has been implicated in a range of neurological and neoplastic disorders, including -related schwannomatosis. We developed a novel human induced pluripotent stem cell (hiPSC) model to study Schwann cell differentiation in health and disease. We performed transcriptomic, immunofluorescence, and morphological analysis of hiPSC derived Schwann cell precursors (SPCs) and terminally differentiated Schwann cells (SCs) representing distinct stages of development.

Association between biological aging and periodontitis using NHANES 2009-2014 and mendelian randomization.

Aging is a recognized risk factor for periodontitis, while biological aging could provide more accurate insights into an individual's functional status. This study aimed to investigate the potential association between biological aging and periodontitis. Epidemiological data from 9803 participants in the 2009-2014 National Health and Nutrition Examination Survey were analyzed at a cross-sectional level to assess this link.

Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes.

Poor skin wound healing, which is common in patients with diabetes, is related to imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general control nonderepressible 2) and its downstream are significantly upregulated in human skin wound tissue and mouse skin wound macrophages, but skin wound-related GCN2 expression and activity are significantly downregulated by diabetes and hyperglycemia. Using wound healing models of GCN2-deleted mice, bone marrow chimeric mice, and monocyte-transferred mice, we show that GCN2 deletion in macrophages significantly delays skin wound healing compared with wild-type mice by altering M1 and M2a/M2c polarization.

Geological and hydrochemical controls on water chemistry and stable isotopes of hot springs in the Three Parallel Rivers Region, southeast Tibetan Plateau: The genesis of geothermal waters.

The Three Parallel Rivers Region (TPRR) is a tectonically active area in the middle segment of the Sanjiang Tethys Orogen, southeast Tibetan Plateau, characterized by many hot springs. This area is up-and-coming for producing geothermal energy, a CO-free energy source, which will help China in reducing the effects of climate change. We report here the results of 37 geothermal springs that have been sampled to investigate the physical and chemical characteristics of the thermal water and evolution patterns.

Protective role of curcumin on broiler liver by modulating aflatoxin B1-induced DNA methylation and CYPs expression.

The purpose of this study was to investigate the role of epigenetic DNA methylation and CYPs expression in AFB1-exposed broiler liver and the protective effect of curcumin. Sixty-four one-day-old AA broilers were randomly divided into four groups, including control group, AFB1 group (1 mg/kg AFB1), curcumin + AFB1 group (1 mg/kg curcumin) and curcumin group (300 mg/kg curcumin). Histological observation, CYP450 enzyme activities, the expression levels of DNA methyltransferases and CYP450 enzymes, and the overall DNA methylation level in broiler liver were investigated.