Publications by authors named "Siheun Lee"
Article Synopsis
- Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a valuable tool for analyzing biological samples, but its effectiveness is limited by the need for an ultrahigh vacuum environment and matrix effects that complicate measurements.
- The study introduces a new platform that allows for quick and efficient quantitative analysis of amino acids using a microarray with freeze-dried solution drops that form matrix deposits.
- By mixing amino acid solutions with stable isotope-labeled phenylalanine and utilizing the microarray setup, the researchers achieved a lower quantitation limit of less than 10 μM for amino acids in their samples.
Biology (Basel)
March 2023
Article Synopsis
- Advances in technology allow for detailed study of individual cells, revealing differences among them in complex biological systems.
- Historically, most research centered on analyzing nucleic acids, while protein and metabolite studies using mass spectrometry (MS) were less developed until now.
- This review highlights the latest progress in MS techniques for single-cell analysis and their implications for understanding biology and medicine.
