Publications by authors named "Siham Hedir"
Article Synopsis
- The research focuses on developing new inhibitors targeting anti-apoptotic proteins, which are crucial in cancer treatment.
- The small molecule MIM1 was reevaluated and its structure corrected, leading to the creation of a library of analogues for testing.
- Biological studies revealed the potential of these new inhibitors, particularly their ability to selectively inhibit the proteins Mcl-1 and Bcl-x, with supporting data from fluorescence polarization assays and molecular modeling.
Protein-protein interactions are attractive targets because they control numerous cellular processes. In oncology, apoptosis regulating Bcl-2 family proteins are of particular interest. Apoptotic cell death is controlled via PPIs between the anti-apoptotic proteins hydrophobic groove and the pro-apoptotic proteins BH3 domain.
View Article and Find Full Text PDFOvarian cancer is the leading cause of death from gynecological malignancies worldwide, and innate or acquired chemoresistance of ovarian cancer cells is the major cause of therapeutic failure. It has been demonstrated that the concomitant inhibition of Bcl-xL and Mcl-1 anti-apoptotic activities is able to trigger apoptosis in chemoresistant ovarian cancer cells. In this context, siRNA-mediated Bcl‑xL and Mcl-1 inhibition constitutes an appealing strategy by which to eliminate chemoresistant cancer cells.
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