Synthesis, characterization and evaluation of antioxidant activities of some novel chalcones analogues.

Background: Chalcone, an important intermediate of flavonoid synthetic pathway, has been shown to exhibit diverse biological and pharmacological activities such as anti- cancer, antioxidant, anti-inflammatory, etc.

Results: In this study, a novel series of chalcones fatty acid esters 5b-e and 6b-e have been synthesized via the reaction of the respective chalcones with either palmitic or stearic acid. Another related class of compounds comprising 2,3-disubstituted chalcones 7b-d and 8b(b')-d as well as 2-amino-6-(substituted-phenyl)-4-substitutedphenyl-nicotinonitrile derivatives 9a,c,e have been also prepared by both electrophilic and Michael addition reactions, respectively, with the corresponding chalcones.

Microwave- and ultrasound-assisted synthesis of some acyclonucleobases based on a uracil moiety using dmap as base.

In this study, 1-(bromoalkanoyl)-1H-pyrimidine-2,4-diones, (2,4-dioxo-pyrimidin-1-yl)-oxo-alkanoic acids, and bis(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-alkanones were successfully prepared via electrophilic substitution of uracil and its derivatives. High yields and pure products were obtained when microwave and ultrasound methodologies were used for undertaking the reactions. Importantly, the use of 4-dimethylaminopyridine in the present investigation gave rise to higher conversions of the starting material and afforded facile access to regioselective N-1 products.