Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development.

Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly for respiratory infections. It is now recognized that these drugs, in particular azithromycin, also exert time-dependent immunomodulatory actions that contribute to their therapeutic benefit in both infectious and other chronic inflammatory diseases. Their increased chronic use in airway inflammation and, more recently, of azithromycin in COVID-19, however, has led to a rise in bacterial resistance.

Numbers and distribution of the Great Cormorant in Iceland: Limitation at the regional and metapopulation level.

We studied a metapopulation of great cormorant in Iceland, using complete aerial censuses of nests in 25 years during 1975-2015. Age composition was estimated in 1998-2014 by ground surveys in September and February. Brood size was estimated from aerial photographs in 2007-2015.