A bibliometric analysis of the clinical development of drugs in Norway for the year 2000.

Purpose:  Bibliometric analysis of publications was used to investigate the research output relating to the development of drugs in Norway and to evaluate the impact of Norwegian involvement in this research.

Material And Methods: One hundred and nine articles published between 2002 and 2008 were analysed. Bibliometric methods used were as follows: information on peer review, impact factor (IF), the Science Citation Index (SCI) and the representation of Norwegians in the list of authors.

An analysis of the clinical development of drugs in Norway for the year 2000: the completion of research and publication of results.

Objective: In Norway, very little data are available on the relation between the total number of research projects on the clinical development of drugs that have been started, the number of these projects in which the research phase has been completed and the number of projects for which results have been published. The aim of this study was to determine the number of projects in which the research phase had been completed and the results published.

Material And Methods: Information on research projects carried out on the clinical development of drugs during the year 2000 was obtained from the archives of the Norwegian Research Ethical Committee (REC) and subsequently analysed.

Twenty-five-year experience with the Medtronic-Hall valve prosthesis in the aortic position: a follow-up cohort study of 816 consecutive patients.

Background: The Medtronic-Hall valve was developed and for the first time implanted in Oslo, Norway, in 1977. A total of 1104 patients received this valve at Rikshospitalet from 1977 to 1987. In the present study, we followed up on all 816 patients undergoing aortic valve replacement over a 25-year period.

An analysis of the clinical development of drugs in Norway for the years 2000 and 2004: the influence of the pharmaceutical industry.

Objective: Little has been published either concerning the total number of research projects in connection with clinical development of drugs or the number of projects financially supported by the industry.

Methods: From the archives of the five regional Norwegian Research Ethical Committees (REC), all research projects in connection with clinical development of drugs for the years 2000 and 2004 were analysed with the intention of finding the number of projects financially supported by the industry, the type of research institution, the industrial company, the topic of the research as classified in the international Anatomic Therapeutic Classification system (ATC), the research phase and the approval status of the drug by the Norwegian Medicines Agency (NMA).

Results: The total number of research projects for the clinical development of drugs for the years 2000 and 2004 was 489, and 75.

Clinical and radiologic outcome of off-pump coronary surgery at 12 months follow-up: a prospective randomized trial.

Background: After more than a decade of experience with off-pump coronary bypass surgery, still no consensus exists concerning its benefit on clinical outcome compared to the on-pump technique. In this 12-month follow-up, we compare off-pump and on-pump surgery on the appearance of graft patency, myocardial function, and clinical outcome.

Methods: One hundred twenty patients were randomized to off-pump or on-pump coronary surgery.

Intraoperative angiography leads to graft revision in coronary artery bypass surgery.

Background: Graft anastomosis quality in coronary artery bypass surgery can be assessed by intraoperative angiography. The aim of the present study was to quantify the on-table revision rate initiated by intraoperative angiography.

Methods: Intraoperative angiography was carried out in 186 patients undergoing coronary artery bypass surgery, with a total of 427 grafts.

Clinical and Angiographic Outcome of Coronary Surgery with and without Cardiopulmonary Bypass: A Prospective Randomized Trial.

Abstract Background: Off-pump coronary artery bypass surgery has emerged as an alternative technique to traditional onpump surgery. The aim of this randomized study was to compare perioperative morbidity and mortality and intraoperative and short-term graft patency in off-pump and on-pump coronary artery bypass grafting. Methods: One hundred twenty patients were randomized for coronary revascularization with or without cardiopulmonary bypass.

Coronary artery bypass grafting combined with aortic valve replacement in healthy octogenarians does not increase postoperative risk.

Objective: Critical aortic stenosis with or without coronary artery disease is increasingly common in octogenarians. Surgery is the treatment of choice, but indications and results of aortic valve replacement (AVR), particularly when combined with coronary artery bypass grafting (CABG) are debated. We investigated whether the combined procedure of AVR and CABG increased postoperative risk compared with isolated AVR in otherwise healthy octogenarians.

The importance of intraoperative angiographic findings for predicting long-term patency in coronary artery bypass operations.

Background: The quality of anastomosis is the cornerstone in coronary artery bypass operations. Intraoperative coronary angiography confirms graft patency with the possibility to revise graft failure. The aim of this study was to describe the lesions found at "on-table" angiography, and to evaluate the significance of these immediate angiographic findings for the long-term patency.