Publications by authors named "Sigrun V Stulz"

Article Synopsis
  • Researchers found biallelic mutations in the DEF6 gene in patients with an immune disorder and systemic autoimmunity, shedding light on how immune responses can malfunction.
  • The study revealed that these mutations disrupt the regulation of the CTLA-4 protein's movement to the surface of T cells, which is crucial for controlling immune responses.
  • The findings suggest that targeting DEF6 could be a potential strategy for treating autoimmune diseases and cancer, as one patient responded well to CTLA-4-Ig treatment.
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