Cognitive test scores in young men and subsequent risk of type 2 diabetes, cardiovascular morbidity, and death.

Background: The association between cognitive scores in young adulthood and long-term cardiometabolic risks remains unclear.

Methods: Using population-based registries, we followed 6502 military conscripts from their 22nd birthday until death, emigration, or 55 years of age. We calculated risks and hazard ratios (HRs) associating quartiles of cognitive scores (very high, high, moderate, and low) with type 2 diabetes, hypertension, myocardial infarction, stroke, venous thromboembolism, and death before age 55 years.

Obesity in young men, and individual and combined risks of type 2 diabetes, cardiovascular morbidity and death before 55 years of age: a Danish 33-year follow-up study.

Objectives: To examine the association between body mass index (BMI) in young adulthood and cardiovascular risks, including venous thromboembolism, before 55 years of age.

Design: Cohort study using population-based medical databases.

Setting: Outcomes registered from all hospitals in Denmark from 1977 onwards.

Hospitalization with acute exacerbation of chronic obstructive pulmonary disease and associated health resource utilization: a population-based Danish cohort study.

Objective: Health resource utilization (HRU) and outcomes associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are not well described. Therefore, a population-based cohort study was conducted to characterize patients hospitalized with AECOPD with regard to HRU, mortality, recurrence, and predictors of readmission with AECOPD.

Methods: Using Danish healthcare databases, this study identified COPD patients with at least one AECOPD hospitalization between 2005-2009 in Northern Denmark.

Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study.

Importance: Excess endogenous cortisol has been linked to venous thromboembolism (VTE) risk, but whether this relationship applies to exogenous glucocorticoids remains uncertain. Because the prevalence of glucocorticoid use and the incidence of VTE are high, an increased risk of VTE associated with glucocorticoid use would have important implications.

Background: To examine the association between glucocorticoid use and VTE.

Use of ß-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study.

Background: Experimental data suggest that catecholamine hormones are involved in stimulating the aggressiveness of ovarian cancer, but few population-based studies have examined this association. We therefore conducted a population-based cohort study to examine whether ß-blockers affect mortality following ovarian cancer diagnosis.

Methods: We used the Danish Cancer Registry to identify all patients diagnosed with ovarian cancer in northern Denmark between 1999 and 2010 (n=6,626).

Existing data sources for clinical epidemiology: The Danish National Database of Reimbursed Prescriptions.

The Danish health care system provides partial reimbursement of most prescription medications in Denmark. The dispensation of prescription medications is registered in administrative databases. Each time a prescription is redeemed at a pharmacy, an electronic record is generated with information related to the user, prescriber, the pharmacy, and the dispensed drug.

Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: a population-based case-control study.

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent the development of cancer by inhibiting cyclooxygenase (COX) enzymes, which are involved in carcinogenesis. Therefore, the authors of this report examined the association between NSAID use and the risk of squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and malignant melanoma (MM).

Methods: From 1991 through 2009, all incident cases of SCC (n = 1974), BCC (n = 13,316), and MM (n = 3242) in northern Denmark were identified.

Mortality in cancer patients with a history of cutaneous squamous cell carcinoma--a nationwide population-based cohort study.

Background: Cutaneous squamous cell carcinoma (SCC) is associated with underlying immunosuppression, so it may be a prognostic marker in patients with subsequent cancer. We therefore conducted a nationwide population-based Danish cohort study to evaluate whether a history of cutaneuos SCC has prognostic impact in patients with one of the following index cancers: non-Hodgkin's lymphoma (NHL), or cancer of the lung, colon, rectum, breast, or prostate.

Methods: We used Danish medical databases, which cover the entire Danish population of 5.

Correspondence between general practitioner-reported medication use and timing of prescription dispensation.

Epidemiologic studies often rely on drug dispensation records to measure medication intake. We aimed to estimate correspondence between general practitioner (GP)-reported treatment and timing of prescription dispensation. From seven GPs in northern Denmark, we obtained 317 prescription records for 286 patients treated with ten commonly prescribed medication types for chronic diseases.